PASTIC Dspace Repository

Reversal of haloperidol induced motor deficits in rats exposed to repeated immobilization stress

Show simple item record

dc.contributor.author Erum Shireen
dc.contributor.author Sidra Pervez
dc.contributor.author Maria Masroor
dc.contributor.author Wafa Binte Ali
dc.contributor.author Qudsia Rais
dc.contributor.author Samira Khalil
dc.contributor.author Anum Tariq
dc.contributor.author Darakshan Jabeen Haleem
dc.date.accessioned 2023-01-20T06:50:04Z
dc.date.available 2023-01-20T06:50:04Z
dc.date.issued 2014-09-09
dc.identifier.citation Shireen, E., Pervez, S., Masroor, M., Ali, W. B., Rais, Q., Khalil, S., ... & Haleem, D. J. (2014). Reversal of haloperidol induced motor deficits in rats exposed to repeated immobilization stress. Pakistan Journal of Pharmaceutical Sciences, 27. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16291
dc.description.abstract Stress is defined as a non specific response of body to any physiological and psychological demand. Preclinical studies have shown that an uncontrollable stress condition produces neurochemical and behavioral deficits. The present study was conducted to test the hypothesis that a decrease in the responsiveness of somatodendritic 5- hydroxytryptamine (5-HT)-1A receptors following adaptation to stress could attenuate haloperidol induced acute parkinsonian like effect. Results showed that single exposure (2h) to immobilization stress markedly decreased food intake, growth rate and locomotor activity but these stress-induced behavioral deficits were not observed following repeated (2h/day for 5 days) exposure of immobilization stress suggesting behavioral tolerance occurs to similar stress. An important finding of present study is a reversal of haloperidol-induced motor deficits in animals exposed to repeated immobilization stress than respective control animals. It is suggested that stress induced possible desensitization of somatodendritic 5-HT-1A as well as 5-HT-2C receptors could release dopamine system from the inhibitory influence of serotonin. On the other hand, an increase in the effectiveness of postsynaptic 5-HT-1A receptors elicits a direct stimulatory influence on the activity of dopaminergic neuron and is possibly involved in the reversal of haloperidolinduced parkinsonian like symptoms in repeatedly immobilized rats. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Haloperidol en_US
dc.subject parkinsonism en_US
dc.subject repeated stress en_US
dc.subject serotonin en_US
dc.subject dopamine en_US
dc.title Reversal of haloperidol induced motor deficits in rats exposed to repeated immobilization stress en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account