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Disintegrants combination: Development and optimization of a cefadroxil fast disintegrating tablet

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dc.contributor.author Najia Rahim
dc.contributor.author Syed Baqir Shyum Naqvi
dc.contributor.author Rehana Bibi
dc.contributor.author Wajiha Iffat
dc.contributor.author Sadia Shakeel
dc.contributor.author Iyad Naeem Muhammad
dc.date.accessioned 2023-01-20T06:50:28Z
dc.date.available 2023-01-20T06:50:28Z
dc.date.issued 2014-09-10
dc.identifier.citation Rahim, N., Shyum Naqvi, S. B., Bibi, R., Iffat, W., Shakeel, S., & Muhammad, I. N. (2014). Disintegrants combination: development and optimization of a cefadroxil fast disintegrating tablet. Pakistan Journal of Pharmaceutical Sciences, 27(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16292
dc.description.abstract Fast Disintegrating Tablets (FDTs) is a rapidly growing dosage form preferred for special population (pediatric, geriatric and psychotic patients). It is also developed with the aim of improving bioavailability and patient compliance. During the present study, cefadroxil fast disintegrating tablets formulations (n=9) were designed and optimized by central composite design with two independent variables (croscarmellose and crospovidone) using design expert® software. The effects of independent variables on formulation properties such as friability, hardness, in vitro dispersion and disintegration were assessed by drawing response surface graphs with design expert® software. Tablets were assessed for pharmacopeial and non-pharmacopeial parameters to ensure the quality of compressed tablets. Among all formulations, F3, F8 and F9 have shown better results. The formulation F9 containing 15mg croscarmellose and 33.075mg crospovidone showed good pharmacotechnical attributes as well as shelf life. F 9 showed improved dissolution with t90% of> 2 min and will lead to better bioavailability. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Fast Disintegrating tablet en_US
dc.subject Croscarmellose en_US
dc.subject Crospovidone en_US
dc.subject Optimization en_US
dc.title Disintegrants combination: Development and optimization of a cefadroxil fast disintegrating tablet en_US
dc.type Article en_US


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