PASTIC Dspace Repository

Effect of caffeine on anti-clotting activity of warfarin in healthy male albino rabbits

Show simple item record

dc.contributor.author Shamaila Zafar
dc.contributor.author Muhammad Mudassar Ashraf
dc.contributor.author Asghar Ali
dc.contributor.author Nosheen Aslam
dc.contributor.author Asma Ashraf
dc.contributor.author Sara Zafar
dc.contributor.author Rahat Andleeb
dc.contributor.author Muhammad Waqas Khadam
dc.contributor.author Imtiaz Mahmood Tahir
dc.contributor.author Muhammad Akram
dc.contributor.author Shah, Syed Muhammad Ali
dc.contributor.author Muhammad Daniyal
dc.date.accessioned 2023-01-20T06:51:29Z
dc.date.available 2023-01-20T06:51:29Z
dc.date.issued 2018-03-03
dc.identifier.citation Zafar, S., Ashraf, M. M., Ali, A., Aslam, N., Ashraf, A., Zafar, S., ... & Daniyal, M. (2018). Effect of caffeine on anti-clotting activity of warfarin in healthy male albino rabbits. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16295
dc.description.abstract Drug-drug interactions are most commonly occurring phenomenon in clinical practice. Many physicians are afraid of being involved in an allegation of malpractices due to the occurrence of any severe interaction. These interactions not only occur between drugs but also between any kind of food, tobacco smoke, caffeine and alcohol etc. Therefore, the present study was directed to inspect the effect of caffeine on the anticoagulation activity of warfarin in healthy adult male albino rabbits. Blank blood samples were collected from each rabbit. Rabbits were given warfarin (0.5mg kg-1) orally via stomach tube and blood samples were collected in PT/INR vials at various intervals. After a washout period of 14 days, warfarin was orally administrated at same dose rate along with caffeine (5 mg kg-1 every twelve hours for three days) and same sampling schedule was repeated. Prothrombin time (PT) and the international normalized ratio (INR) of blood samples were determined to estimate changes in the anticoagulation activity of warfarin after its concurrent administration with caffeine. The PT data revealed that Rmax and AUC increased significantly (P≤0.05) from 1991.6 and 60.5 to 2124.8 and 67.5, respectively, before and after co-administration. Similarly, a significant (P≤0.05) increase was observed in Rmax and AUC of INR from 6.42 and 153.7 to 7.4 and 167.5, respectively, alone and along with caffeine. However, no change was observed in Tmax associated with PT and INR either the drug was administered alone or in combination with caffeine. It was concluded that caffeine has the capacity to inhibit the metabolism of warfarin and enhance its plasma concentration and hence anticoagulant effects. Thus, patients should be advised to limit the frequent use of caffeine-rich products i.e. tea and coffee during warfarin therapy. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Anticoagulant therapy en_US
dc.subject drug interaction en_US
dc.subject coffee en_US
dc.subject tea en_US
dc.title Effect of caffeine on anti-clotting activity of warfarin in healthy male albino rabbits en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account