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Prevalence of statin induced myopathy in Lahore, Pakistan

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dc.contributor.author Saleha Sadeeqa
dc.contributor.author Mariam Maqsood
dc.contributor.author Maqsood Ahmad
dc.date.accessioned 2023-01-20T06:51:49Z
dc.date.available 2023-01-20T06:51:49Z
dc.date.issued 2018-03-04
dc.identifier.citation Sadeeqa, S., Maqsood, M., & Ahmad, M. (2018). Prevalence of statin induced myopathy in Lahore, Pakistan. Pakistan journal of pharmaceutical sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16296
dc.description.abstract Cardiovascular diseases are considered to be the leading cause of disability and deaths in the whole world. The major cause behind this disease is the formation of lipid plagues in the form of thrombus. The statins (HMG-CoA reductase inhibitors) are used for the treatment and prevention of hyperlipidemia. Myopathy is the major side effect caused by statins. The purpose of this study was to determine the prevalence of statin induced myopathy. A crosssectional study design was adopted using convenient random sampling technique at Punjab Institute of Cardiology, Lahore Pakistan from November 2016 to February 2017. A total of 300 male and female patients were included having age range of 40-80 years. Data was collected directly from the patients and prevalence of myalgia was determined by the symptoms of the patients. Creatine Phospho Kinase levels were obtained of those patients showing symptoms. Data was analyzed by using SPSS version 21. The results showed that 51% patients were myalgic with mean±SEM, 1.49±0.29. Myalgia was more prevalent in age range 40-50, with females 57% and males 47%. Significant relation was found between myalgia and type of statin (p=0.05), duration of use of statin (p=0.036) and dose of statin (p=0.031). The study concludes that the prevalence of myalgia was not significant but females were more prone to myalgic symptoms as compared to males. It was further concluded that myalgic symptoms were directly related to dose and duration & type of statin use. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Myalgia en_US
dc.subject Statin en_US
dc.subject Prevalence en_US
dc.subject CPK en_US
dc.subject Myopathy en_US
dc.subject HMG-CoA en_US
dc.title Prevalence of statin induced myopathy in Lahore, Pakistan en_US
dc.type Article en_US


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