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Ameliorative effect of hydro-methanolic extract from roots of Rauwolfia serpentina on some biochemical parameters of type 1 diabetic mice

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dc.contributor.author Muhammad Bilal Azmi
dc.contributor.author Shamim A. Qureshi
dc.contributor.author Syed Danish Haseen Ahmed
dc.contributor.author Hina Akram Mudassir
dc.contributor.author Fauzia Imtiaz
dc.contributor.author Sumera Rais
dc.contributor.author Khan, Auwais Ahmed
dc.contributor.author Muhammad Ahsan
dc.date.accessioned 2023-01-20T06:54:16Z
dc.date.available 2023-01-20T06:54:16Z
dc.date.issued 2018-03-10
dc.identifier.citation Azmi, M. B., Qureshi, S. A., Ahmed, S. D. H., Mudassir, H. A., Imtiaz, F., Rais, S., ... & Ahsan, M. (2018). Ameliorative effect of hydro-methanolic extract from roots of Rauwolfia serpentina on some biochemical parameters of type 1 diabetic mice. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16303
dc.description.abstract Present work seeks to investigate the biochemical parameters in terms of hypoglycemic and hypolipidemic effects of hydro-methanolic roots extract (HyMREt) of Rauwolfia serpentina in type 1 (alloxan induced) diabetic mice. Animals were divided into seven groups, four control groups, and three were test groups (HyMREt at 50, 100, & 150mg/kg). Each treatment was repeated for 14 days regularly in all seven respective groups and afterwards the body weights, fasting blood glucose (FBG), insulin, and serum lipid levels were determined. Total body weights of diabetic mice treated with HyMREt extract were dose dependently (p≤0.05) improved. FBG of test groups were significantly (p ≤ 0.0001) reduced in comparison with diabetic controls which displayed elevated fasting blood glucose level. The insulin levels of HyMREt treated groups were significantly (p≤0.0001) higher than those of diabetic controls. Lower triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) whereas elevated level of high density lipoprotein cholesterol (HDL-c) were observed in test dose treated groups. In comparison with diabetic controls, the converse levels of serum lipid were observed. Significant improvement in cardio- protective indices and coronary risk index was also observed. Findings of present study support the hypoglycemic and hypolipidemic potential of HyMREt of R. serpentina. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Alloxan en_US
dc.subject glucose en_US
dc.subject lipid en_US
dc.subject Rauwolfia serpentina en_US
dc.title Ameliorative effect of hydro-methanolic extract from roots of Rauwolfia serpentina on some biochemical parameters of type 1 diabetic mice en_US
dc.type Article en_US


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