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Incidence of drug interactions in intensive care units in tertiary care settings: Classification, facts and measures

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dc.contributor.author Hina Hasnain
dc.contributor.author Huma Ali
dc.contributor.author Farya Zafar
dc.contributor.author Ali Akbar Sial
dc.contributor.author Shazia Alam
dc.contributor.author Anwar Ejaz Beg
dc.contributor.author Rabia Bushra
dc.contributor.author Mehwish Rizvi
dc.contributor.author Khan, Maqsood Ahmed
dc.contributor.author Huma Shareef
dc.contributor.author Ghazala R Naqvi
dc.contributor.author Anum Tariq
dc.date.accessioned 2023-01-20T06:54:37Z
dc.date.available 2023-01-20T06:54:37Z
dc.date.issued 2018-03-11
dc.identifier.citation Hasnain, H., Ali, H., Zafar, F., Sial, A. A., Alam, S., Beg, A. E., ... & Tariq, A. (2018). Incidence of drug interactions in intensive care units in tertiary care settings: Classification, facts and measures. Pakistan journal of pharmaceutical sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16304
dc.description.abstract Drug-drug interactions (DDIs) are extremely significant concern, particularly in sensitive population including pediatric and geriatric. Propensity for the development of DDIs is high in patients admitted at intensive care units (ICU). This study was conducted to evaluate the DDIs incidence, facts and measures in ICU. From a total of 150 cases studied for ICU patients, with the mean age of 56.37±12.45 years, 55.33% were male and the rest were female 44.66%. The demographic information like age, gender and main diagnosis details of study participants that were extracted from the patients’ clinical record. A statistically significant association between the drug interaction and the number of drugs prescribed per prescription was observed (p<0.0001). Concerning the onset of outcome, 52% of DDIs distinguished as delayed onset of effect (past 24 hours) and 35% were categorized as rapid onset (within 24 hours). Despite the facts regarding patient safety and minimizing DIs error, polypharmacy is still frequent in critically ill patients admitted in ICU attributed high risk of adverse reactions due to use of multiple interventions to treat severity of disease condition. Such studies may be used to develop an effective tool for the diagnosis and management of DDIs. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Drug interactions en_US
dc.subject ICU en_US
dc.subject geriatric en_US
dc.subject incidence en_US
dc.subject facts en_US
dc.title Incidence of drug interactions in intensive care units in tertiary care settings: Classification, facts and measures en_US
dc.type Article en_US


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