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Interaction of palladium inorganic salt and organic complex with glutathione content of liver homogenate

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dc.contributor.author Muhammad Mukhtiar
dc.contributor.author Syed Umer Jan
dc.contributor.author IhsanUllah
dc.contributor.author Rahman Gul
dc.contributor.author Abid Hussain
dc.contributor.author Essa Ali
dc.contributor.author IzharUllah
dc.contributor.author Abdul Jabbar
dc.contributor.author Muhammad Akram
dc.contributor.author Sibghat Mansoor
dc.contributor.author Khan, Muhammad Farid
dc.date.accessioned 2023-01-20T06:57:07Z
dc.date.available 2023-01-20T06:57:07Z
dc.date.issued 2018-03-18
dc.identifier.citation Mukhtiar, M., Jan, S. U., Gul, R., Hussain, A., Ali, E., Jabbar, A., ... & Khan, M. F. (2018). Interaction of palladium inorganic salt and organic complex with glutathione content of liver homogenate. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16311
dc.description.abstract Glutathione is an essential antioxidant of living organism that provides a primary protection against metals toxicity. A significant amount of glutathione is present in blood erythrocytes, plasma and liver hepatocytes to protect them from oxidative damage from both external and internal oxidants. Metalo-element palladium has numerous pharmacological, clinical and toxicological compensations, like palladium is used as anti-viral, anti-bacterial, neuroprotective and anti-tumor agent. However studies have also indicated some mild to serious toxic effects of palladium metallo-elements. In the presence study the interaction of palladium inorganic salt and organic complex with glutathione (GSH) content of liver homogenate was examined spectro- photometrically. 20% (w/v) liver homogenate was prepared of the collected liver of rabbit in 5% TCA (tri-chloro-acetic acid) solution and 1mm EDTA, using a potter-eveljhem homogenizer with motor driven Teflon pestle. The GSH content quantification was carried out by Elman’s method. Our finding showed that there was a depletion of GSH content by both palladium inorganic salts and organic complexes, concentrations wise as well as with time elapse as level of GSH content decrease from (43.6% to 72.62%) with Palladium Nitrate and from (24.09 to 59.5%) with Bis-benzonitrile Palladium II Chloride as compared to control, and further dropped with time incubation from 0-90 minutes from (49.7 to 87.1%), with Palladium Nitrate and from (29.3% to 67.6%) respectively. The result showed that the effect of both inorganic salt of palladium was more enhanced as compare to its organic complex. It was suggested from our finding that the depletion in the glutathione content of liver homogenate may be due to oxidation of glutathione or due to glutathione metal abduct formation by both inorganic salt and organic complex of palladium. This study in situ is a model of in vivo. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Glutathione (GSH) en_US
dc.subject palladium en_US
dc.subject spectrophotometer en_US
dc.subject Elman’s method en_US
dc.subject rabbit liver homogenate en_US
dc.title Interaction of palladium inorganic salt and organic complex with glutathione content of liver homogenate en_US
dc.type Article en_US


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