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Annona squamosa Linn: Cytotoxic activity found in leaf extract against human tumor cell lines

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dc.contributor.author Wang, De-Shen
dc.contributor.author Ghazala H Rizwani
dc.contributor.author Guo, Huiqin
dc.contributor.author Mansoor Ahmed
dc.contributor.author Maryam Ahmed
dc.contributor.author Syed Zeeshan Hassan
dc.contributor.author Amir Hassan
dc.contributor.author Chen, Zhe-Sheng
dc.contributor.author Xu, Rui-Hua
dc.date.accessioned 2023-01-20T07:02:04Z
dc.date.available 2023-01-20T07:02:04Z
dc.date.issued 2014-09-23
dc.identifier.citation Wang, D. S., Rizwani, G. H., Guo, H., Ahmed, M., Ahmed, M., Hassan, S. Z., ... & Xu, R. H. (2014). Annona squamosa Linn: cytotoxic activity found in leaf extract against human tumor cell lines. Pak J Pharm Sci, 27(5), 1559-1563. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16323
dc.description.abstract Cancer is a common cause of death in human populations. Surgery, chemotherapy and radiotherapy still remain the corner stone of treatment. However, herbal medicines are gaining popularity on account of their esser harmful side effects on non-targeted human cells and biological environment. Annona squamosa Linn is a common delicious edible fruit and its leaf have been used for the treatment in various types of diseases. The objective of present study is to determine the anticancer potential of the organic and aqueous extracts of leaf of Annona squamosa L. MTT (3-(4, 5-dimethylthiazole-2yl)-2, 5-biphenyl tetrazolium bromide) assay against hepatocellular carcinoma cell line BEL7404, lung cancer line H460, human epidermoid carcinoma cell line KB-3-1, prostatic cancer cell line DU145, breast carcinoma cell line MDA-MB-435, and colon cancer cell line HCT-116 Human primary embryonic kidney cell line HEK293 as control were used for the study. The crude extract (Zcd) and Ethyl acetate extract (ZE) were found significant anticancer activity only on human epidermoid carcinoma cell line KB-3-1 and colon cancer cell line HCT116. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Annona squamosa Linn en_US
dc.subject custard apple en_US
dc.subject leaf en_US
dc.subject cancer cell lines en_US
dc.subject cytotoxicity en_US
dc.title Annona squamosa Linn: Cytotoxic activity found in leaf extract against human tumor cell lines en_US
dc.type Article en_US


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