PASTIC Dspace Repository

Methylphenidate‐induced hepatotoxicity in rats and its reduction by buspirone

Show simple item record

dc.contributor.author Nausheen Alam
dc.contributor.author Rahila Ikram
dc.date.accessioned 2023-01-20T07:03:39Z
dc.date.available 2023-01-20T07:03:39Z
dc.date.issued 2018-05-02
dc.identifier.citation Alam, N., & Ikram, R. (2018). Methylphenidate-induced hepatotoxicity in rats and its reduction by buspirone. Pakistan Journal of Pharmaceutical Sciences, 31(3), 741-745. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16329
dc.description.abstract Methylphenidate is commonly use for the treatment of attention deficit hyperactivity disorder (ADHD), but its long term use was found to produce hepatic necrosis in mice. Purpose of this study was to investigate that coadministration of buspirone (drug which attenuates methylphenidate induced sensitization) may attenuate methylphenidate-induced hepatotoxic effects and to determine the effect of challenge dose of haloperidol (D2 antagonist that blocks the effects of methylphenidate in case of intoxication) on SGPT and SGOT levels in methylphenidate treated rats. Estimation of SGPT and SGOT were performed using kit method. Prolong oral administration of methylphenidate at a dose of 2.0 mg/kg/day, buspirone at a dose of 10 mg/kg/day, their co-administration and challenge dose of haloperidol (1 mg/kg i.p.) in rats increased SGPT concentration and decreased SGOT concentration, effect is more pronounced in methylphenidate treated rats and potentiate with administration of haloperidol challenge dose. In conclusion our analysis showed that methylphenidate and challenge dose of haloperidol is associated with elevation of SGPT in rats, which is attenuate in co-administration of methylphenidate buspirone treated rats. To quantify the risk of methylphenidate-induced hepatic injury and role of buspirone to reduce the injury further pharmacoepidemiological investigations are required. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Methylphenidate en_US
dc.subject SGPT en_US
dc.subject SGOT en_US
dc.subject buspirone en_US
dc.subject haloperidol en_US
dc.title Methylphenidate‐induced hepatotoxicity in rats and its reduction by buspirone en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account