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Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus

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dc.contributor.author Abdur Rauf
dc.contributor.author Usama Shaheen
dc.contributor.author Muslim Raza
dc.contributor.author Ghias Uddin
dc.contributor.author Taibi Ben Hadda
dc.contributor.author Yahia Nasser Mabkhot
dc.contributor.author Noor Jehan
dc.contributor.author Bashir Ahmad
dc.contributor.author Saleem Raza
dc.contributor.author Molnar, Joseph
dc.contributor.author Csonka, Ákos
dc.contributor.author Szabó, Diána
dc.date.accessioned 2023-01-20T07:07:22Z
dc.date.available 2023-01-20T07:07:22Z
dc.date.issued 2018-05-13
dc.identifier.citation Rauf, A., Shaheen, U., Raza, M., Uddin, G., Hadda, T. B., Mabkhot, Y. N., ... & Szabó, D. (2018). Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus. Pakistan Journal of Pharmaceutical Sciences, 31(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16340
dc.description.abstract A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Diospyros lotus en_US
dc.subject Di-naphthodiospyrol R en_US
dc.subject anticancer en_US
dc.subject molecular docking en_US
dc.title Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus en_US
dc.type Article en_US


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