dc.contributor.author | Abdur Rauf | |
dc.contributor.author | Usama Shaheen | |
dc.contributor.author | Muslim Raza | |
dc.contributor.author | Ghias Uddin | |
dc.contributor.author | Taibi Ben Hadda | |
dc.contributor.author | Yahia Nasser Mabkhot | |
dc.contributor.author | Noor Jehan | |
dc.contributor.author | Bashir Ahmad | |
dc.contributor.author | Saleem Raza | |
dc.contributor.author | Molnar, Joseph | |
dc.contributor.author | Csonka, Ákos | |
dc.contributor.author | Szabó, Diána | |
dc.date.accessioned | 2023-01-20T07:07:22Z | |
dc.date.available | 2023-01-20T07:07:22Z | |
dc.date.issued | 2018-05-13 | |
dc.identifier.citation | Rauf, A., Shaheen, U., Raza, M., Uddin, G., Hadda, T. B., Mabkhot, Y. N., ... & Szabó, D. (2018). Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus. Pakistan Journal of Pharmaceutical Sciences, 31(3). | en_US |
dc.identifier.issn | 1011-601X | |
dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/16340 | |
dc.description.abstract | A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi | en_US |
dc.subject | Diospyros lotus | en_US |
dc.subject | Di-naphthodiospyrol R | en_US |
dc.subject | anticancer | en_US |
dc.subject | molecular docking | en_US |
dc.title | Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus | en_US |
dc.type | Article | en_US |