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Delivery of risperidone from gels across porcine skin in vitro and in vivo in rabbits

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dc.contributor.author Ning, Yuming
dc.contributor.author Chen, Xiaojin
dc.contributor.author Yu, Zhenwei
dc.contributor.author Liang, Wenquan
dc.contributor.author Li, Fanzhu
dc.date.accessioned 2023-01-20T07:09:35Z
dc.date.available 2023-01-20T07:09:35Z
dc.date.issued 2018-05-21
dc.identifier.citation Ning, Y., Chen, X., Yu, Z., Liang, W., & Li, F. (2018). Delivery of risperidone from gels across porcine skin in vitro and in vivo in rabbits. Pakistan Journal of Pharmaceutical Sciences, 31(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16348
dc.description.abstract The purpose of this study was to develop and evaluate a transdermal delivery system for RIS using hydrogels. First, the effects of different concentrations of hydroxypropyl methylcellulose and Carbomer 934 (CBR) on RIS permeation were investigated in porcine skin. The optimized formulation was chosen as the base gel to screen for penetration enhancers. The pharmacokinetics of the optimized RIS formulation was then studied in vitro in rabbits. A formulation with 0.5% CBR showed the highest RIS permeation and was selected as the base gel. RIS permeation was further increased by incorporation of Azone, lauryl alcohol, or menthol, and the enhancing effects of the three were dosedependent. When each enhancer combined with propylene glycol (PG) a synergistic effect was found. A combination of 6% menthol and 6% PG exhibited highest RIS in vitro penetration rate and showed a high efficiency in vivo, with a relative bioavailability of 131.53% compared with intragastric administration. These findings showed that 1% RIS in 0.5% CBR, containing a combination of 6% menthol and 6% PG, can deliver doses of RIS that are therapeutically relevant for treating patients with schizophrenia. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Risperidone en_US
dc.subject Transdermal en_US
dc.subject Gel en_US
dc.subject Penetration enhancer en_US
dc.subject Pharmacokinetic en_US
dc.title Delivery of risperidone from gels across porcine skin in vitro and in vivo in rabbits en_US
dc.type Article en_US


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