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Therapeutic effect evaluation of reteplase on acute pulmonary embolism

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dc.contributor.author Wang, Wanping
dc.contributor.author Zhao, Xianping
dc.contributor.author Ren, Yingjie
dc.contributor.author Qiao, Ping
dc.date.accessioned 2023-01-20T07:10:05Z
dc.date.available 2023-01-20T07:10:05Z
dc.date.issued 2018-05-23
dc.identifier.citation Wang, W., Zhao, X., Ren, Y., & Qiao, P. (2018). Therapeutic effect evaluation of reteplase on acute pulmonary embolism. Pakistan journal of pharmaceutical sciences, 31(3), 899-906. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16350
dc.description.abstract Thrombolysis is the main therapeutic method of acute pulmonary embolism (APE). In order to investigate the efficacy of reteplase on APE and the changes of cytokines in the progression of APE, 72 patients with APE were randomized into reteplase group and urokinase group which received reteplase thrombolysis and urokinase thrombolysis, respectively. The clinical symptoms, blood pressure, heart rate (HR), blood gas index and cytokines of patients were observed before and after therapy for assessing the thrombolysis effect of each group; blood level of high sensitive Creactive protein (hs-CRP), TNF-α, IL-1β, IL-6 and IL-10 was detected at 0h, 2h, 6h, 12h and 24h after thrombolysis. After treatment, the clinical symptoms of both groups were alleviated obviously; PaO2, PaCO2, blood pressure and HR in both groups were significantly improved than those before treatment (p<0.001), and reteplase group showed a more obvious improvement than urokinase group (p<0.001). Since 6h after therapy, the content of hs-CRP, IL-1β and IL-6 in patients of reteplase group declined significantly (p<0.05 or 0.01). In conclusion, therapeutic effect of reteplase is better than urokinase, hs-CRP, IL-1β and IL-6 can be used to monitor the thrombolysis efficacy of APE patients. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Reteplase en_US
dc.subject acute pulmonary embolism en_US
dc.subject cytokine en_US
dc.subject inflammation en_US
dc.title Therapeutic effect evaluation of reteplase on acute pulmonary embolism en_US
dc.type Article en_US


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