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HYPOPHAGIC AND HYPOLOCOMOTIVE EFFECTS OF METACHLORO PHENYL PIPERAZINE IN RATS TREATED WITH THEOPHYLLINE AND CAFFEINE

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dc.contributor.author NAUSHEEN ALAM
dc.contributor.author HALEEM, DARAKSHAN JABEEN
dc.contributor.author RAHILA NAJAM
dc.contributor.author SYEDA HAIDER
dc.contributor.author AHMED, SHAHIDA PERVEEN
dc.date.accessioned 2023-01-20T07:12:08Z
dc.date.available 2023-01-20T07:12:08Z
dc.date.issued 2011-07-20
dc.identifier.citation Alam, N., Haleem, D. J., Najam, R., Haider, S., & Ahmed, S. P. (2011). Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine. Pak J Pharm Sci, 24(3), 251-254. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16357
dc.description.abstract Long term intake of coffee is known to produce anxiety and suppression of appetite. 5- hydroxytryptamine (5- HT) acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor metachloro phenyl piperazine (m-CPP) at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine (a component of coffee and tea) or theophylline (a component of tea) as a sole source of water. We found that hypophagic and hypolocomotive effects of m-CPP were attenuated in theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may attenuate anorexiogenic and anxiogenic effects of 5-HT. A possible role of 5-HT-2C receptors in the modulation of anxiety and appetite in people drinking coffee or tea discussed. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Anxiety en_US
dc.subject anorexia, m-CPP en_US
dc.subject caffeine, theophylline en_US
dc.title HYPOPHAGIC AND HYPOLOCOMOTIVE EFFECTS OF METACHLORO PHENYL PIPERAZINE IN RATS TREATED WITH THEOPHYLLINE AND CAFFEINE en_US
dc.type Article en_US


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