dc.contributor.author |
NAUSHEEN ALAM |
|
dc.contributor.author |
HALEEM, DARAKSHAN JABEEN |
|
dc.contributor.author |
RAHILA NAJAM |
|
dc.contributor.author |
SYEDA HAIDER |
|
dc.contributor.author |
AHMED, SHAHIDA PERVEEN |
|
dc.date.accessioned |
2023-01-20T07:12:08Z |
|
dc.date.available |
2023-01-20T07:12:08Z |
|
dc.date.issued |
2011-07-20 |
|
dc.identifier.citation |
Alam, N., Haleem, D. J., Najam, R., Haider, S., & Ahmed, S. P. (2011). Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine. Pak J Pharm Sci, 24(3), 251-254. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16357 |
|
dc.description.abstract |
Long term intake of coffee is known to produce anxiety and suppression of appetite. 5- hydroxytryptamine (5-
HT) acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor
metachloro phenyl piperazine (m-CPP) at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine (a component of coffee and tea) or theophylline (a component of tea) as a sole
source of water. We found that hypophagic and hypolocomotive effects of m-CPP were attenuated in
theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may attenuate
anorexiogenic and anxiogenic effects of 5-HT. A possible role of 5-HT-2C receptors in the modulation of
anxiety and appetite in people drinking coffee or tea discussed. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
en_US |
dc.subject |
Anxiety |
en_US |
dc.subject |
anorexia, m-CPP |
en_US |
dc.subject |
caffeine, theophylline |
en_US |
dc.title |
HYPOPHAGIC AND HYPOLOCOMOTIVE EFFECTS OF METACHLORO PHENYL PIPERAZINE IN RATS TREATED WITH THEOPHYLLINE AND CAFFEINE |
en_US |
dc.type |
Article |
en_US |