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Potential impact of Panax ginseng against ethanol induced hyperlipidemia and cardiac damage in rats

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dc.contributor.author Najla Othman Ayaz
dc.contributor.author Hanan Saeed Alnahdi
dc.date.accessioned 2023-01-20T07:12:24Z
dc.date.available 2023-01-20T07:12:24Z
dc.date.issued 2018-05-27
dc.identifier.citation Ayaz, N. O., & Alnahdi, H. S. (2018). Potential impact of Panax ginseng against ethanol induced hyperlipidemia and cardiac damage in rats. Pakistan Journal of Pharmaceutical Sciences, 31(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16358
dc.description.abstract The objective of the current work was to explore the possible hypolipidemic and therapeutic impacts of Panax ginseng against cardiac damage in response to ethanol ingestion in male and female rats. 10% ethanol was ingested (2ml/Kg) to both male and female rats daily for fourteen days. The results showed that ingestion of ginseng (150mg/Kg) daily for six weeks to male and female rats intoxicated with ethanol, two weeks after ethanol ingestion, successfully modulated the alterations in the serum lipid profiles, namely, triglycerides (TGs), total cholesterol (TCh), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C), in male and female rats exposed to ethanol versus untreated intoxicated ones. The plant also pronouncedly attenuated the increases in serum cardiac damage biomarkers, namely lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) compared with ethanol intoxicated untreated rats. In conclusion, this study showed that Panax ginseng has a beneficial impact against ethanol induced hyperlipidemia as a risk element for cardiovascular illness. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Panax ginseng en_US
dc.subject ethanol en_US
dc.subject hyperlipidemia en_US
dc.subject cardiac damage en_US
dc.title Potential impact of Panax ginseng against ethanol induced hyperlipidemia and cardiac damage in rats en_US
dc.type Article en_US


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