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Prolonged oral cyanide effects on feed intake, growth rate and blood parameters in rabbits

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dc.contributor.author Muhammad Avais
dc.contributor.author Khan, Muhammad Sarwar
dc.contributor.author Khan, Muhammad Arif
dc.contributor.author Kamran Ashraf
dc.date.accessioned 2023-01-20T07:13:21Z
dc.date.available 2023-01-20T07:13:21Z
dc.date.issued 2014-07-04
dc.identifier.citation Avais, M., Khan, M. S., Khan, M. A., Ashraf, K., Khan, J. A., & Hameed, S. (2014). Prolonged oral cyanide effects on feed intake, growth rate and blood parameters in rabbits. Pakistan Journal of Pharmaceutical Sciences, 27(4), 773-778. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16361
dc.description.abstract Twelve adult rabbits bred locally were divided into two equal groups of 6; experimental and control groups. Rabbits in the experimental group were orally dosed with KCN at 3mg/kg body weight for 40 consecutive days. Members in control group were given placebo (distilled water) for the same period. Animals in both groups were offered feed at 90gm/kg/day while ample drinking water was available ad lib. Feed consumption and body weight of rabbits in both the groups were recorded. Blood samples were also drawn to determine various hematological parameters. Statistical analysis revealed a non-significant difference of total and daily feed intakes in rabbits of experimental and control groups. Whereas the feed efficiency of rabbits in the xperimental group were significantly reduced (P<0.05) compared to controls. Likewise a significant decrease in body eight gain of rabbits in experimental group (P<0.05) was observed. A non-significant difference (P>0.05) was bserved in leukocyte count, differential leukocyte count and platelets of rabbits in both the groups. Erythrocyte count, hemoglobin concentration, packed cell volume and mean corpuscular hemoglobin were significantly decreased in treated rabbits. It was concluded that chronic cyanide intake had a deleterious effect on feed efficiency, growth rate and blood components of rabbits. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Cyanide en_US
dc.subject feed intake en_US
dc.subject erythrocytes en_US
dc.subject growth rate en_US
dc.title Prolonged oral cyanide effects on feed intake, growth rate and blood parameters in rabbits en_US
dc.type Article en_US


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