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The preparation of the sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed

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dc.contributor.author Cao, Jin
dc.contributor.author Liu, Hongfei
dc.contributor.author Pan, Weisan
dc.contributor.author Sun, Changshan
dc.contributor.author Feng, Yingshu
dc.contributor.author Zhong, Hui
dc.contributor.author Shi, Shuang Shuang
dc.contributor.author He, Yan
dc.date.accessioned 2023-01-20T07:14:11Z
dc.date.available 2023-01-20T07:14:11Z
dc.date.issued 2014-07-05
dc.identifier.citation Cao, J., Liu, H., Pan, W., Sun, C., Feng, Y., Zhong, H., ... & He, Y. (2014). The preparation of the sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed. Pak. J. Pharm. Sci, 27(4), 779-784. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16364
dc.description.abstract The main objective of this study was to prepare sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed and to obtain the optimized coating process and formulation. Fine microcapsules without agglomeration were obtained in a continuous coating process with the atomization air pressure of 0.2Mpa and an appropriate coating speed temperature. With other design variables of coating process fixed, the effects of different fluidizing air volume, coating temperature, coating speed, coating material, coating materials amount, plasticizer type and plasticizer amount on drug release were investigated respectively. Coating solution was achieved by dissolving EC45cps of 21 g, EC100cps of 7 g, DBS of 2.8 g and talcum powder of 8 g in ethanol to get a final volume of 500 ml. Particles of 150g along with 500mL coating solution would be fine. The results showed that with the air volume of 35 m3 ·h-1, coating temperature of 35o coating speed of 6 mL·min-1 and proper amount of coating solution, fine microcapsules were obtained. The mean diameter of the microcapsules obtained eventually were 213 µm and the drug content were 23%, which was suitable for producing a suspension. Particle diameter distribution corresponded to the normal distribution and obviously prolonged drug-release was achieved. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Wurster fluidized bed en_US
dc.subject metformin hydrochloride en_US
dc.subject ion-exchange resin en_US
dc.subject sustained-release microcapsule en_US
dc.subject suspension en_US
dc.title The preparation of the sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed en_US
dc.type Article en_US


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