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FORMULATION AND IN VITRO EVALUATION OF OFLOXACIN-ETHOCEL CONTROLLED RELEASE MATRIX TABLETS PREPARED BY WET GRANULATION METHOD: INFLUENCE OF CO-EXCIPIENTS ON DRUG RELEASE RATES

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dc.contributor.author SHAH, SHEFAAT ULLAH
dc.contributor.author SHAH, KIFAYAT ULLAH
dc.contributor.author JAN, SYED UMER
dc.contributor.author KAMRAN AHMAD
dc.contributor.author ASIM-UR-REHMAN
dc.contributor.author ABID HUSSAIN
dc.contributor.author KHAN, GUL MAJID
dc.date.accessioned 2023-01-20T07:18:49Z
dc.date.available 2023-01-20T07:18:49Z
dc.date.issued 2011-07-20
dc.identifier.citation Shah, S. U., Shah, K. U., Jan, S. U., Ahmad, K., Rehman, A., Hussain, A., & Khan, G. M. (2011). Formulation and in vitro evaluation of ofloxacin-ethocel controlled release matrix tablets prepared by wet granulation method: Influence of co-excipients on drug release rates. Pak. J. Pharm. Sci, 24(3), 255-261. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16368
dc.description.abstract Being controlled release dosage forms, tablets allow an improved absorption and release profiles of Ofloxacin. The fact that drugs with fine particles size can be compressed well after wetting, so in our research studies Ofloxacin controlled release matrix tablets were prepared by wet granulation technique. In order to investigate the potential of Ethyl cellulose ether derivatives as a matrix material, Ofloxacin formulations with different types and grades of Ethocel were prepared at several drug-to-polymer ratios. The method adopted for in vitro drug release studies was USP Method-1 (rotating Basket Method) by Pharma test dissolution apparatus using phosphate buffer 7.4 pH as a dissolution medium. Various Kinetic models were employed to the formulations for the purpose of determination of release mechanism. A comparative study was performed between the tested Ofloxacin-Ethocel formulations and a standard reference obtained from the local market. F1 dissimilarity factor and f2 similarity factor were applied to the formulations for the checking of dissimilarities and similarities between the tested formulations and reference standard. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Ofloxacin en_US
dc.subject Ethocel standard 7 en_US
dc.subject 10 and 100 premium and FP premium en_US
dc.subject wet granulation en_US
dc.subject controlled release matrices en_US
dc.subject release kinetics and patterns en_US
dc.subject effect of co-excipients en_US
dc.title FORMULATION AND IN VITRO EVALUATION OF OFLOXACIN-ETHOCEL CONTROLLED RELEASE MATRIX TABLETS PREPARED BY WET GRANULATION METHOD: INFLUENCE OF CO-EXCIPIENTS ON DRUG RELEASE RATES en_US
dc.type Article en_US


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