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NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN

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dc.contributor.author NASEER, MUHAMMAD IMRAN
dc.contributor.author IKRAM ULLAH
dc.contributor.author NAJEEB ULLAH
dc.contributor.author LEE, HAE YOUNG
dc.contributor.author CHEON, EUN WOO
dc.contributor.author JONGIL CHUNG
dc.contributor.author KIM, MYEONG OK
dc.date.accessioned 2023-01-20T07:21:29Z
dc.date.available 2023-01-20T07:21:29Z
dc.date.issued 2011-07-20
dc.identifier.citation Naseer, M. I., Ullah, I., Ullah, N., Lee, H. Y., Cheon, E. W., Chung, J., & Kim, M. O. (2011). Neuroprotective effect of vitamin C against PTZ induced apoptotic neurodegeneration in adult rat brain. Pakistan journal of pharmaceutical sciences, 24(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16370
dc.description.abstract The present study was designed to observe the effect of PTZ on expression of caspsae-3, and to evaluate the neuroprotective role of vitamin C (vit-C) against PTZ-induced apoptotic neurodegeneration in adult rat brain. We observed that administration of a single conclusive dose of pentylenetetrazol (PTZ 50mg/kg) in adults rats induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. Further, rats were injected with vit-C (250 mg/kg) 30 min before PTZ injection. The protective effect of vit-C against PTZinduced apoptotic neurodegeneration in adult rat brain was observed using Western blot analysis and Nissl staining. The results showed that conclusive dose of PTZ-induced seizure, increased expression of caspase-3 and neuronal apoptosis in adult rat brain. Whereas, the pretreatment of vit-C along with PTZ showed significantly decreased expression of caspase-3 as compare to control group. Finally, our results indicated that vit-C can prevent some of the deleterious effect of seizure and neuronal degeneration induced by PTZ in adult rat brain. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject PTZ en_US
dc.subject neurodegeneration en_US
dc.subject vitamin C en_US
dc.subject adult rat brain en_US
dc.title NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN en_US
dc.type Article en_US


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