dc.contributor.author |
NASEER, MUHAMMAD IMRAN |
|
dc.contributor.author |
IKRAM ULLAH |
|
dc.contributor.author |
NAJEEB ULLAH |
|
dc.contributor.author |
LEE, HAE YOUNG |
|
dc.contributor.author |
CHEON, EUN WOO |
|
dc.contributor.author |
JONGIL CHUNG |
|
dc.contributor.author |
KIM, MYEONG OK |
|
dc.date.accessioned |
2023-01-20T07:21:29Z |
|
dc.date.available |
2023-01-20T07:21:29Z |
|
dc.date.issued |
2011-07-20 |
|
dc.identifier.citation |
Naseer, M. I., Ullah, I., Ullah, N., Lee, H. Y., Cheon, E. W., Chung, J., & Kim, M. O. (2011). Neuroprotective effect of vitamin C against PTZ induced apoptotic neurodegeneration in adult rat brain. Pakistan journal of pharmaceutical sciences, 24(3). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16370 |
|
dc.description.abstract |
The present study was designed to observe the effect of PTZ on expression of caspsae-3, and to evaluate the
neuroprotective role of vitamin C (vit-C) against PTZ-induced apoptotic neurodegeneration in adult rat brain.
We observed that administration of a single conclusive dose of pentylenetetrazol (PTZ 50mg/kg) in adults rats
induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. Further, rats were
injected with vit-C (250 mg/kg) 30 min before PTZ injection. The protective effect of vit-C against PTZinduced apoptotic neurodegeneration in adult rat brain was observed using Western blot analysis and Nissl
staining. The results showed that conclusive dose of PTZ-induced seizure, increased expression of caspase-3
and neuronal apoptosis in adult rat brain. Whereas, the pretreatment of vit-C along with PTZ showed
significantly decreased expression of caspase-3 as compare to control group. Finally, our results indicated that
vit-C can prevent some of the deleterious effect of seizure and neuronal degeneration induced by PTZ in adult
rat brain. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
en_US |
dc.subject |
PTZ |
en_US |
dc.subject |
neurodegeneration |
en_US |
dc.subject |
vitamin C |
en_US |
dc.subject |
adult rat brain |
en_US |
dc.title |
NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN |
en_US |
dc.type |
Article |
en_US |