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Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical

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dc.contributor.author Muhammad Khalid
dc.contributor.author Tanveer Hussain Bokhari
dc.contributor.author Mushtaq Ahmad
dc.contributor.author Haq Nawaz Bhatti
dc.contributor.author Munawar Iqbal
dc.contributor.author Abdul Ghaffar
dc.contributor.author Muhammad Imran Qadir
dc.date.accessioned 2023-01-20T07:22:44Z
dc.date.available 2023-01-20T07:22:44Z
dc.date.issued 2014-07-10
dc.identifier.citation Khalid, M., Bokhari, T. H., Ahmad, M., Bhatti, H. N., Iqbal, M., Ghaffar, A., & Qadir, M. I. (2014). Evaluation of carrier added and no carrier added 90 Y-EDTMP as bone seeking therapeutic radiopharmaceutical. Pakistan Journal of Pharmaceutical Sciences, 27(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16372
dc.description.abstract The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with 90y as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be obtained by 89y (n,γ) 90y nuclear reaction in a reactor or from an in-house generator system (90sr→90y). The preparation of 90Y-EDTMPis described using 90y, which was obtained from neutron radiation of y2o3 as well as from a laboratory scale organic resin-based 90sr→90y generator. Because of the adiolabeling yield of 90Y-EDTMP on ligand/metal molar ratio, incubation time and ph was evaluated. Under optimum parameters, the radiolabeling yields of 90Y-EDTMPwere <95% for no-carrier-added as well as carrier-added 90y. The biodistribution of no-carrier-added and carrier-added 90YEDTMPcomplexes in rats was identical. The results indicate that 90y (carrier-added)-edtmp is also an effective bone pain palliation agent because of its rapid blood clearance, greater uptake in bones and little absorption in soft tissues. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Carrier-added Yttrium-90 en_US
dc.subject No-carrier-added Yttrium-90 en_US
dc.subject Strontium-90/Yttrium-90 generator en_US
dc.subject EDTMP en_US
dc.subject Biodistribution in rats en_US
dc.title Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical en_US
dc.type Article en_US


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