dc.contributor.author |
Muhammad Khalid |
|
dc.contributor.author |
Tanveer Hussain Bokhari |
|
dc.contributor.author |
Mushtaq Ahmad |
|
dc.contributor.author |
Haq Nawaz Bhatti |
|
dc.contributor.author |
Munawar Iqbal |
|
dc.contributor.author |
Abdul Ghaffar |
|
dc.contributor.author |
Muhammad Imran Qadir |
|
dc.date.accessioned |
2023-01-20T07:22:44Z |
|
dc.date.available |
2023-01-20T07:22:44Z |
|
dc.date.issued |
2014-07-10 |
|
dc.identifier.citation |
Khalid, M., Bokhari, T. H., Ahmad, M., Bhatti, H. N., Iqbal, M., Ghaffar, A., & Qadir, M. I. (2014). Evaluation of carrier added and no carrier added 90 Y-EDTMP as bone seeking therapeutic radiopharmaceutical. Pakistan Journal of Pharmaceutical Sciences, 27(4). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16372 |
|
dc.description.abstract |
The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with 90y
as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be obtained by 89y (n,γ) 90y nuclear reaction in a reactor or from an in-house generator system (90sr→90y). The preparation of 90Y-EDTMPis described using 90y, which was obtained from neutron radiation of y2o3 as well as from a laboratory scale organic resin-based 90sr→90y generator. Because of the adiolabeling yield of 90Y-EDTMP on ligand/metal molar ratio, incubation time and ph was evaluated. Under optimum parameters, the radiolabeling yields of 90Y-EDTMPwere <95% for no-carrier-added as well as carrier-added 90y. The biodistribution of no-carrier-added and carrier-added 90YEDTMPcomplexes in rats was identical. The results indicate that 90y (carrier-added)-edtmp is also an effective bone pain palliation agent because of its rapid blood clearance, greater uptake in bones and little absorption in soft tissues. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy, University of Karachi |
en_US |
dc.subject |
Carrier-added Yttrium-90 |
en_US |
dc.subject |
No-carrier-added Yttrium-90 |
en_US |
dc.subject |
Strontium-90/Yttrium-90 generator |
en_US |
dc.subject |
EDTMP |
en_US |
dc.subject |
Biodistribution in rats |
en_US |
dc.title |
Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical |
en_US |
dc.type |
Article |
en_US |