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Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats

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dc.contributor.author Noor Aisyah Ismail
dc.contributor.author Nor Syafawati Shamsahal Din
dc.contributor.author Siti Syariah Mamat
dc.contributor.author Zalina Zabidi
dc.contributor.author Wan Noraziemah Wan Zainulddin
dc.contributor.author Farah Hidayah Kamisan
dc.contributor.author Farhana Yahya
dc.contributor.author Norhafizah Mohtarrudin
dc.contributor.author Mohd Nasir Mohd Desa
dc.contributor.author Zainul Amiruddin Zakaria
dc.date.accessioned 2023-01-20T07:24:20Z
dc.date.available 2023-01-20T07:24:20Z
dc.date.issued 2014-07-13
dc.identifier.citation Ismail, N. A., Shamsahal Din, N. S., Mamat, S. S., Zabidi, Z., Wan Zainulddin, W. N., Kamisan, F. H., ... & Zakaria, Z. A. (2014). Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats. Pakistan journal of pharmaceutical sciences, 27(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16377
dc.description.abstract The present study aimed to determine the hepatoprotective activity of Dicranopteris linearis L. (family Gleicheniaceae) leaf aqueous extract (DLAE) using two models of liver injury in rats. Rats were divided into ten groups (n=6) and received dH2O (negative control), 200 mg/kg silymarin (positive control) or DLAE (50, 250 and 500 mg/kg) orally once daily for 7 consecutive days and on the 8th day subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, only the highest dose of DLAE significantly (p<0.05) reduced the ALP, ALT and AST levels in CCl4-and PCM-induced hepatotoxic rats while the other doses caused significant (p<0.05) reduction only in the levels of ALT and AST. The histological results obtained were in line with the biochemical analysis wherein reduction in the CCl4- and PCM-induced tissue formation of necrosis, steatosis and inflammation occurred in a dose-dependent manner. In conclusion, the DLAE possesses hepatoprotective activity, which could be attributed to its free radicals scavenging and antioxidant activities, and high flavonoids content. Thus, in-depth studies regarding the hepatoprotective activity of DLAE are warranted. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Dicranopteris linearis en_US
dc.subject Gleicheniaceae en_US
dc.subject in vivo en_US
dc.subject hepatoprotective activity en_US
dc.subject aqueous extract en_US
dc.subject leaves en_US
dc.title Effect of aqueous extract of Dicranopteris linearis leaves against paracetamol and carbon tetrachloride-induced liver toxicity in rats en_US
dc.type Article en_US


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