dc.contributor.author |
Yuan, Huaibo |
|
dc.contributor.author |
Meng, Shaohua |
|
dc.contributor.author |
Wang, Guoze |
|
dc.contributor.author |
Gong, Zhaobin |
|
dc.contributor.author |
Sun, Wenkai |
|
dc.contributor.author |
He, Guoqing |
|
dc.date.accessioned |
2023-01-20T07:25:29Z |
|
dc.date.available |
2023-01-20T07:25:29Z |
|
dc.date.issued |
2014-07-17 |
|
dc.identifier.citation |
Yuan, H., Meng, S., Wang, G., Gong, Z., Sun, W., & He, G. (2014). Hypoglycemic effect of triterpenoid-rich extracts from Euryale ferox shell on normal and streptozotocin-diabetic mice. Pakistan Journal of Pharmaceutical Sciences, 27(4). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16381 |
|
dc.description.abstract |
The antioxidant effects of the triterpenoid-rich extracts from Euryale ferox shell (ES) have been confirmed in
vitro. This study examined whether the triterpenoid-rich extract from ES eases human hyperglycemia and diabetes caused by metabolic disorders. Normal and streptozocin (STZ)-induced diabetic mice were used as controls for the four groups that received the triterpenoid-rich extracts of ES suspended in distilled water orally at doses of 200, 300, 400, 500±2 mg/L. Body weight, blood glucose and pancreatic tissue morphology were observed after 4 weeks. The expression of protein tyrosine phosphatase-1B (PTP1B) and insulin receptor substrate (IRS-1) proteins, which are related to the regulation of glucose metabolism in vivo, were also investigated. Compared with the model group (LD50 900±2 mg/L), it was found that the triterpenoid-rich extracts of ES could regulate glucose metabolism (P<0.01) and cause body weight to return to normal levels (P<0.05). Islet morphology recovered well, the expression of the negative regulation protein PTP1B gene was reduced and insulin receptor IRS-1 protein expression was increased. These data prove that the triterpenoid-rich extracts from ES have a therapeutic effect on diabetes by insulin resistance. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy, University of Karachi |
en_US |
dc.subject |
Euryale |
en_US |
dc.subject |
diabetes |
en_US |
dc.subject |
insulin resistance |
en_US |
dc.title |
Hypoglycemic effect of triterpenoid-rich extracts from Euryale ferox shell on normal and streptozotocin-diabetic mice |
en_US |
dc.type |
Article |
en_US |