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Unpredictable chronic mild stress induced behavioral deficits: A comparative study in male and female rats

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dc.contributor.author Muhammad Farhan
dc.contributor.author Huma Ikram
dc.contributor.author Sumera Kanwa
dc.contributor.author Darakhshan Jabeen Haleem
dc.date.accessioned 2023-01-20T07:26:05Z
dc.date.available 2023-01-20T07:26:05Z
dc.date.issued 2014-07-20
dc.identifier.citation Farhan, M., Ikram, H., Kanwal, S., & Haleem, D. J. (2014). Unpredictable chronic mild stress induced behavioral deficits: a comparative study in male and female rats. Pakistan Journal of Pharmaceutical Sciences, 27(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16383
dc.description.abstract Stress is an important precipitant factor for depression. Changes in various body systems that occur in depression are similar to those observed in response to stress. Chronic stress may alter behavioral, neurochemical and physiological responses to drug challenges and novel stressors. Unpredictable chronic mild stress (UCMS) also produces alteration in the serotonergic (5-HT; 5-hydroxytryptamine) eurotransmission. Unpredictable chronic mild stress (UCMS) could be used as an animal model of depression. Neurochemical and behavioral effects of UCMS can be reversed by antidepressant agents, suggesting an important role of serotonin. In rodents, UCMS can elicit depression-like symptoms. The objective of the present study was to evaluate and compare the behavioral deficits induced by chronic mild stress in male and female rats and finding out the vulnerability of the two groups. Male and female rats exposed to UCMS exhibited a significant decrease in cumulative food intake as well as in growth rate. Loco motor activity in home cage and open field was also decreased. Results may contribute to our understanding of the interaction between stress and behavioral functions have to depressive disorders. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Unpredictable chronic mild stress en_US
dc.subject depression en_US
dc.subject sex difference en_US
dc.subject Locomotor activity en_US
dc.title Unpredictable chronic mild stress induced behavioral deficits: A comparative study in male and female rats en_US
dc.type Article en_US


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