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EVALUATION OF PHYTOCONSTITUENTS AND ANTI-NEPHROTOXIC AND ANTIOXIDANT ACTIVITIES OF MONOCHORIA VAGINALIS

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dc.contributor.author SUBRAMANI PALANI
dc.contributor.author SUNDARARAJAN RAJA
dc.contributor.author KUMAR, RAMANUJAM PRAVEEN
dc.contributor.author RANGANATHAN SELVARAJ
dc.contributor.author KUMAR, BALASUBRAMANIAN SENTHIL
dc.date.accessioned 2023-01-20T07:26:39Z
dc.date.available 2023-01-20T07:26:39Z
dc.date.issued 2011-07-20
dc.identifier.citation Palani, S., Raja, S., Kumar, R. P., Selvaraj, R., & Kumar, B. S. (2011). Evaluation of phytoconstituents and anti-nephrotoxic and antioxidant activities of Monochoria vaginalis. Pakistan Journal of Pharmaceutical Sciences, 24(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16385
dc.description.abstract Monochoria vaginalis is an herbaceous medicinal plant used to treat, liver problems India. Acetaminophen is a commonly used analgesic and antipyretic agent which, at high doses, causes liver and kidney necrosis in man and animals. The aim of the present study is to evaluate phytoconstituents and investigate the nephroprotective & antioxidant activities of the ethanol extract of Monochoria vaginalis on acetaminophen induced toxicity in rats. Phytoconstituents like n-hexadecanoic acid, 3-methyl- acetate-1-butanol, 1,1,3-triethoxy- propane, Z,Z,Z1,4,6,9 - nonadecatetraene, undecanoic acid, 3-trifluoroacetoxy penta decane and 4-ethyl-5-octyl-2,2-bis (trifluoromethyl) - cis-1,3-dioxalone were identified from ethanol extract of Monochoria vaginalis by using a gas chromatograph-mass spectrograph (GC MS). Biochemical studies show that there is an increase in the levels of serum urea and creatinine along with an increase in the body weight and reduction in the levels of uric acid in acetaminophen induced groups. These values are retrieved significantly by treatment with Monochoria vaginalis extracts at two different doses. The antioxidant studies reveal that the levels of renal SOD, CAT, GSH and GPx in the APAP treated animals are increased significantly along with a reduced MDA content in ethanol extract of Monochoria vaginalis treated groups. Apart from these, histopathological changes also reveal the protective nature of the Monochoria vaginalis extract against acetaminophen induced necrotic damage of renal tissues. In conclusion, these data suggest that the ethanol extract of Monochoria vaginalis can prevent renal damage from APAP induced nephrotoxicity in rats and it is likely to be mediated through active phytoconstituents and its antioxidant activities. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Monochoria vaginalis en_US
dc.subject antioxidant en_US
dc.subject acetaminophen en_US
dc.subject nephroprotective. en_US
dc.title EVALUATION OF PHYTOCONSTITUENTS AND ANTI-NEPHROTOXIC AND ANTIOXIDANT ACTIVITIES OF MONOCHORIA VAGINALIS en_US
dc.type Article en_US


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