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Formulation and evaluation of suspensions: Mefenamic acid prodrugs

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dc.contributor.author Kamal Shah
dc.contributor.author Sushant K
dc.contributor.author Shrivastava
dc.contributor.author Pradeep Mishra
dc.date.accessioned 2023-01-20T07:28:55Z
dc.date.available 2023-01-20T07:28:55Z
dc.date.issued 2014-07-25
dc.identifier.citation Shah, K., Shrivastava, S. K., & Mishra, P. (2014). Formulation and evaluation of suspensions: Mefenamic acid prodrugs. Pakistan journal of pharmaceutical sciences, 27(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16392
dc.description.abstract Gastrosparing novel prodrugs (MAM and MAT) synthesized consisted of mefenamic acid (MA) with menthol (M) and thymol (T). Structural characterizations of synthesized esters were done by Infra red spectroscopy (IR), proton nuclear magnetic resonance (1 HNMR), mass spectroscopy. After evaluation of pharmacological i.e. anti-inflammatory, analgesic and ulcerogenic activities, the preformulation studies were undertaken. Based on these a few formulation (suspensions) were designed and prepared. The formulated suspensions were evaluated for content uniformity, sedimentation volume, recovery studies, redispersibility, viscosity, pH, particle size, zeta potential, effect of temperature and in-vitro dissolution rate. All the above parameters were found to be within the limit these indicated that the synthesized esters are good candidate for liquid dosage form. Thus it can be concluded synthesized prodrugs can be formulated in suspension form. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Mutual prodrug en_US
dc.subject mefenamic acid en_US
dc.subject suspensions, dissolution en_US
dc.subject preformulation en_US
dc.title Formulation and evaluation of suspensions: Mefenamic acid prodrugs en_US
dc.type Article en_US


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