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Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5o C)

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dc.contributor.author Shaista Zafar
dc.contributor.author Shamim Akhtar
dc.contributor.author Talat Tariq
dc.contributor.author Noushin Mushtaq
dc.contributor.author Arfa Akram
dc.contributor.author Ahsaan Ahmed
dc.contributor.author Muhammad Arif
dc.contributor.author Sabahat Naeem
dc.contributor.author Sana Anwar
dc.date.accessioned 2023-01-20T07:29:12Z
dc.date.available 2023-01-20T07:29:12Z
dc.date.issued 2014-07-26
dc.identifier.citation Zafar, S., Akhtar, S., Tariq, T., Mushtaq, N., Akram, A., Ahmed, A., ... & Anwar, S. (2014). Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5° C). Pakistan Journal of Pharmaceutical Sciences, 27(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16393
dc.description.abstract Dissociation constant (pKa) of ten novel phenacyl derivatives of piperidine were determined by potentiometric titration method in aqueous medium at room temperature (25 ±0.5o C). The sample solutions were prepared in deionized water with ionic strength 0.01M and titrated with 0.1M NaOH solution. In addition, ∆G values were also calculated. Different prediction software programs were used to calculate pKa values too and compared to the experimentally observed pKa values. The experimental and theoretical values were found in close agreement. The results obtained in this research would help to predict the good absorption of the studied compounds and can be selected as lead molecules for the synthesis of CNS active agents because of their lipophilic nature especially compound VII. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Dissociation constant en_US
dc.subject phenacyl derivatives en_US
dc.subject CNS active agents en_US
dc.subject potentiometry en_US
dc.subject lipophilicit en_US
dc.subject pH partition theory en_US
dc.title Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5o C) en_US
dc.type Article en_US


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