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REPORT Antipyretic activity of hydro-alcoholic extracts of Moringa oleifera in rabbits

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dc.contributor.author Saeed Ahmad
dc.contributor.author Syed Muhammad Ali Shah
dc.contributor.author Muhammad Khurshid Alam
dc.contributor.author Khan Usmanghani
dc.contributor.author Iqbal Azhar
dc.contributor.author Muhammad Akram
dc.date.accessioned 2023-01-20T07:29:27Z
dc.date.available 2023-01-20T07:29:27Z
dc.date.issued 2014-07-27
dc.identifier.citation Ahmad, S., Shah, S. M. A., Alam, M. K., Usmanghani, K., Azhar, I., & Akram, M. (2014). of Moringa oleifera in rabbits. Pak. J. Pharm. Sci, 27(4), 931-934. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16394
dc.description.abstract Pyrexia and inflammation are indicatives of various disorders. Modern medicines are available for treatment of pyrexia, but they have few side effects. Several studies are ongoing Worldwide to search natural antipyretic agents with better efficacy and fewer or no side effects. This study was aimed at evaluating the antipyretic activity of Moringa oleifera bark in rabbits against E. coli induced pyrexia. Rectal temperature was recorded with digital thermometer at 0 h and E.coli suspension was injected. After 1 h again rectal temperature of the animals was recorded and hydro-alcoholic extract were administered to the treatment groups and paracetamol hydro-alcoholic 50 mg/kg orally to the positive control group. Then rectal temperature was recorded at the interval of one h for 4 h. After the drug administration (at h 1), the decrease in body temperature with the dose of 25mg/kg-1 during next four h ranged between 1.9-2.6o F as compared to the negative control. At the dose of 50mg/kg-1 the decrease in temperature was 1.9-3.0 o F. The decrease in body temperature at the dose of 100mg/kg-1 was high, which ranged from 2.3-3.1o F as compared to negative control. Paracetamol, a standard drug , also significantly lowered the temperature but Moringa oleifera at the concentration of 100mg/kg-1 lowered the body temperature significantly as compared to the negative as well as positive control. Moringa oleifera bark has marked antipyretic activity in animal models and this strongly supports the ethnopharmacological uses of Moringa oleifera bark as an antipyretic plant. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Escherichia coli en_US
dc.subject Cholistan desert en_US
dc.subject analgesic en_US
dc.subject anti-inflammatory en_US
dc.subject prostaglandin en_US
dc.subject E. coli induced pyrexia en_US
dc.subject traditional medicine en_US
dc.title REPORT Antipyretic activity of hydro-alcoholic extracts of Moringa oleifera in rabbits en_US
dc.type Article en_US


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