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Ameliorating role of methanolic leaves extract of Fraxinus xanthoxyloides against CCl4-challanged nephrotoxicity in rats

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dc.contributor.author Tahira Younis
dc.contributor.author Azhar Rasul
dc.contributor.author Faiza Jabeen
dc.contributor.author Ghulam Hussain
dc.contributor.author Javaria Altaf
dc.contributor.author Laila Jafri
dc.contributor.author Rehana Rani
dc.contributor.author Khan, Muhammad Rashid
dc.contributor.author Iqra Sarfraz
dc.contributor.author Muhammad Ali
dc.date.accessioned 2023-01-20T07:30:54Z
dc.date.available 2023-01-20T07:30:54Z
dc.date.issued 2018-07-05
dc.identifier.citation Younis, T., Rasul, A., Jabeen, F., Hussain, G., Altaf, J., Jafri, L., ... & Ali, M. (2018). Ameliorating role of methanolic leaves extract of Fraxinus xanthoxyloides against CCl 4-challanged nephrotoxicity in rats. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16399
dc.description.abstract Roots, bark, stem/twigs, and leaves of Fraxinus xanthoxyloides are being used regionally for the cure of malaria, jaundice, internal injuries, pneumonia, pain, rheumatism and also in fracture of bones. Our objective was to assess the methanolic leaves extract of F. xanthoxyloides for its antioxidant capability against oxidative stress induced by carbon tetrachloride (CCl4) in the kidney of Sprague-Dawley rats. Duration of this experiment was 30 days and doses were given on alternative days. Urine of rats was assessed for kidney function and renal tissues for antioxidant enzymes activity, biochemical markers, comet assay and histopathology. Enhanced urinary creatinine, urobilinogen levels and decreased creatinine clearance, protein contents, and albumin levels were observed by CCl4 administration when matched to controls. CCl4 injection also decreased the level of reduced glutathione, catalase, super oxide dismutase, peroxidase, glutathione s-transferase, glutathione reductase, and tissue protein while elevated the levels of thiobarbituric acid reactive substances, DNA damages and H2O2 in renal tissues of experimental animals. Co-treatment of FXM and silymarin, lead to the restoration of all the above tested parameters of kidney. Through this study we affirmed the ameliorating role of F. xanthoxyloides in oxidative stress affiliated disorders of kidney. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Fraxinus xanthoxyloides en_US
dc.subject phenolics en_US
dc.subject antioxidant en_US
dc.subject kidney en_US
dc.title Ameliorating role of methanolic leaves extract of Fraxinus xanthoxyloides against CCl4-challanged nephrotoxicity in rats en_US
dc.type Article en_US


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