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Post interferon therapy decreases male fertility through gonadotoxic effect

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dc.contributor.author Shazia Anwer Bukhari
dc.contributor.author Muhammad Masood Ahmed
dc.contributor.author Fozia Anjum
dc.contributor.author Haseeb Anwar
dc.contributor.author Syed Ali Raza Naqvi
dc.contributor.author Tauseef Zahra
dc.contributor.author Uzma Batool
dc.date.accessioned 2023-01-20T07:34:17Z
dc.date.available 2023-01-20T07:34:17Z
dc.date.issued 2018-07-17
dc.identifier.citation Bukhari, S. A., Ahmed, M. M., Anjum, F., Anwar, H., Naqvi, S. A. R., Zahra, T., & Batool, U. (2018). Post interferon therapy decreases male fertility through gonadotoxic effect. Pak J Pharm Sci, 31(4 Suppl), 1565-1570. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16410
dc.description.abstract Prevalence of hepatitis C virus (HCV) has been seen in more than 15% of Pakistani population. For the treatment of this infection, only two medicines, interferon, and ribavirin were approved in 1998. The concerned physicians evaluate side effects of these two antiviral drugs only during the treatment period. The long-term extra hepatic side effects are being neglected. This retrospective study was conducted with reference to induced infertility in HCV treated 40 male patients from the period 2008-2015. Possible effects of interferon therapy on fertility hormones and seminal parameters were assessed. Level of fertility hormones like serum Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), and testosterone was measured. For seminal parameters, guidelines from World Health Organization (WHO) were followed. Among forty cases of HCV patients who received interferon, only 14 (35%) have children and 26 (65%) could not conceive (p = 0.0372). After HCV treatment, HCV positive patients showed a significant change in the level of FSH, LH (p<0.05). Especially, it decreased testosterone level (p=0.0096). Similarly, HCV treatment significantly decreased sperm count (p = 0.001) and motility (p = 0.0005). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Gonadotoxicity en_US
dc.subject interferon en_US
dc.subject fertility hormones en_US
dc.subject seminal parameters en_US
dc.subject male fertility en_US
dc.title Post interferon therapy decreases male fertility through gonadotoxic effect en_US
dc.type Article en_US


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