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High performance liquid chromatographic method validation for determination of rosuvastatin calcium in tablet dosage forms

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dc.contributor.author Madiha Moid
dc.contributor.author Sidra Afzal
dc.contributor.author Najia Rahim
dc.contributor.author Tariq Ali
dc.contributor.author Wajiha Iffat
dc.contributor.author Lubna Bashir
dc.contributor.author Shazia Naz
dc.date.accessioned 2023-01-20T07:34:54Z
dc.date.available 2023-01-20T07:34:54Z
dc.date.issued 2018-07-18
dc.identifier.citation Moid, M., Afzal, S., Rahim, N., Ali, T., Iffat, W., Bashir, L., & Naz, S. (2018). High performance liquid chromatographic method validation for determination of rosuvastatin calcium in tablet dosage forms. Pak. J. Pharm. Sci, 31(4), 1577-1582. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16412
dc.description.abstract A precise, sensitive and quick High Performance Liquid Chromatographic (HPLC) method for the determination of rosuvastatin calcium in bulk and tablet dosage forms has been validated. The chromatographic scheme involved: Sil-20A auto sampler, LC-20A pump, SPD-20A UV/visible detector with separation attained by C18 column at 40ºC temperature through a mobile phase of acetonitrile and buffer (50:50) at a flow rate of 1.0ml/min. The method is precise (%RSD for intra-day and inter-day extended between 1.06-1.54% and 0.103-1.78%) and linear (r2 =0.9997). Limit of detection and quantification (LOD & LOQ) of the adopted method were 0.78 and 1.56µg/ml. The proposed HPLC method was established to be sensitive, precise and swift that can be proficiently adopted in quality control/quality assurance laboratories for predictable investigation of the bulk and oral solid dosage forms of rosuvastatin calcium. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Rosuvastatin calcium en_US
dc.subject intra-day en_US
dc.subject inter-day en_US
dc.title High performance liquid chromatographic method validation for determination of rosuvastatin calcium in tablet dosage forms en_US
dc.type Article en_US


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