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ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF DIFFERENT FRACTIONS OF COCCINIA CORDIFOLIA L. ON NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS

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dc.contributor.author MD. ARIFUL ISLAM
dc.contributor.author KHAN, RAFIQUL ISLAM
dc.contributor.author SAROWAR HOSSAIN
dc.contributor.author KHURSHID ALAM
dc.contributor.author IMAM IBNE WAHED
dc.contributor.author BYTUL M. RAHMAN
dc.contributor.author ASM ANISUZZAMAN
dc.contributor.author SHARIF MD. SHAHEEN
dc.date.accessioned 2023-01-20T07:35:12Z
dc.date.available 2023-01-20T07:35:12Z
dc.date.issued 2011-07-20
dc.identifier.citation Islam, M. A., Khan, M. D., Hossain, M. S., Alam, A. K., Wahed, M. I. I., Rahman, B. M., ... & Ahmed, M. (2011). Antidiabetic and hypolipidemic effects of different fractions of Coccinia cordifolia L. on normal and streptozotocin-induced diabetic rats. Pakistan Journal of Pharmaceutical Sciences, 24(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16413
dc.description.abstract The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia Linn. (150 mg/kg body weight) on normal and streptozotocin (STZ)-induced diabetic rats for one day experiment. Single doses (150 mg/kg, i.p.) of C. cordifolia extracts were given to normal and diabetic rats. The fasting blood glucose (FBG), serum triglyceride (TG) and serum total cholesterol (TC) levels were investigated in normal and STZ-diabetic rats on 0, 1, 2, 3, 6, 10, 16, and 24th hours. In normoglycemic rats the pet-ether and ethyl acetate fractions of C. cordifolia reduced blood glucose level significantly (39.66% and 40.68% at 16th and 24th hour respectively). In the STZ-diabetic rats pet-ether and ethyl acetate fractions also reduced blood glucose level significantly (50.39% and 50% at 10th and 24th hour respectively). Ethyl acetate fraction is most effective which reduced total cholesterol level by 31.04% and 36.69% in normal and STZ-diabetic rats respectively. Ethyl acetate fraction reduced triglyceride level by 43.82% and 42.01% in normal and STZ-diabetic rats respectively. Our results indicate that pet-ether and ethyl acetate fractions of C. cordifolia have potentiality against diabetes. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Coccinia cordifolia en_US
dc.subject hypoglycemic en_US
dc.subject antihyperglycemic en_US
dc.subject hypolipidemic en_US
dc.subject streptozotocin induced diabetic rats. en_US
dc.title ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF DIFFERENT FRACTIONS OF COCCINIA CORDIFOLIA L. ON NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS en_US
dc.type Article en_US


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