dc.contributor.author |
MD. ARIFUL ISLAM |
|
dc.contributor.author |
KHAN, RAFIQUL ISLAM |
|
dc.contributor.author |
SAROWAR HOSSAIN |
|
dc.contributor.author |
KHURSHID ALAM |
|
dc.contributor.author |
IMAM IBNE WAHED |
|
dc.contributor.author |
BYTUL M. RAHMAN |
|
dc.contributor.author |
ASM ANISUZZAMAN |
|
dc.contributor.author |
SHARIF MD. SHAHEEN |
|
dc.date.accessioned |
2023-01-20T07:35:12Z |
|
dc.date.available |
2023-01-20T07:35:12Z |
|
dc.date.issued |
2011-07-20 |
|
dc.identifier.citation |
Islam, M. A., Khan, M. D., Hossain, M. S., Alam, A. K., Wahed, M. I. I., Rahman, B. M., ... & Ahmed, M. (2011). Antidiabetic and hypolipidemic effects of different fractions of Coccinia cordifolia L. on normal and streptozotocin-induced diabetic rats. Pakistan Journal of Pharmaceutical Sciences, 24(3). |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16413 |
|
dc.description.abstract |
The present study was carried out to observe the antidiabetic and hypolipidemic effects of petroleum-ether,
ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia Linn.
(150 mg/kg body weight) on normal and streptozotocin (STZ)-induced diabetic rats for one day experiment.
Single doses (150 mg/kg, i.p.) of C. cordifolia extracts were given to normal and diabetic rats. The fasting blood
glucose (FBG), serum triglyceride (TG) and serum total cholesterol (TC) levels were investigated in normal and
STZ-diabetic rats on 0, 1, 2, 3, 6, 10, 16, and 24th hours. In normoglycemic rats the pet-ether and ethyl acetate fractions of C. cordifolia reduced blood glucose level significantly (39.66% and 40.68% at 16th and 24th hour respectively). In the STZ-diabetic rats pet-ether and ethyl acetate fractions also reduced blood glucose level significantly (50.39% and 50% at 10th and 24th hour respectively). Ethyl acetate fraction is most effective which reduced total cholesterol level by 31.04% and 36.69% in normal and STZ-diabetic rats respectively. Ethyl acetate fraction reduced triglyceride level by 43.82% and 42.01% in normal and STZ-diabetic rats respectively. Our results indicate that pet-ether and ethyl acetate fractions of C. cordifolia have potentiality against diabetes. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
en_US |
dc.subject |
Coccinia cordifolia |
en_US |
dc.subject |
hypoglycemic |
en_US |
dc.subject |
antihyperglycemic |
en_US |
dc.subject |
hypolipidemic |
en_US |
dc.subject |
streptozotocin induced diabetic rats. |
en_US |
dc.title |
ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF DIFFERENT FRACTIONS OF COCCINIA CORDIFOLIA L. ON NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS |
en_US |
dc.type |
Article |
en_US |