Abstract:
Moxifloxacin and lomefloxacin are fluoroquinolone antibiotics used in treating urinary and respiratory tract
infections. Fluoroquinolones are known to have interactions with drugs that are active in gastro intestinal
tract. Being moxifloxacin and lomefloxacin fluoroquinolones the interaction study of was carried out with
sucralfate, gelusil, erythromycin and multi minerals. The interaction was studied at neutral, acidic and basic
conditions both at room temperature and 37°C. The effect of dissolution medium simulating various body
environments with response to pH has been examined in order to elucidate the interactions. The response of
moxifloxacin and lomefloxacin after interaction with co-administered drugs at different conditions and
temperature were noted using a Shimadzu HPLC system with PDA detector. It was seen that interaction of
these fluoroquinolones was more at 37ºC than at room temperature. Moxifloxacin and Lomefloxacin reacts
faster with sucralfate and gelusil in acidic media whereas with erythromycin in basic media and multiminerals in neutral media. The study ensures the interaction of fluoroquinolones with selected class of
drugs. In order to achieve the effective therapeutic effect appropriate time intervals between
administrations of drugs is essential.
