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EFFECTS OF AEGELINE, A MAIN ALKALOID OF AEGLE MARMELOS CORREA LEAVES, ON THE HISTAMINE RELEASE FROM MAST CELLS

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dc.contributor.author NUGROHO, AGUNG ENDRO
dc.contributor.author SUGENG RIYANTO
dc.contributor.author SUKARI, MOHAMAD ASPOLLAH
dc.contributor.author KAZUTAKA MAEYAMA
dc.date.accessioned 2023-01-20T07:38:18Z
dc.date.available 2023-01-20T07:38:18Z
dc.date.issued 2011-07-20
dc.identifier.citation Nugroho, A. E., Riyanto, S., Sukari, M. A., & Maeyama, K. (2011). Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pakistan journal of pharmaceutical sciences, 24(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16424
dc.description.abstract Aegeline or N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from Aegle marmelos Correa collected in Yogyakarta Indonesia. In our study, we investigated the effects of aegeline on the histamine release from mast cell. The study was performed by using (1) rat basophilic leukemia (RBL2H3) cell line, and (2) rat peritoneal mast cells (RPMCs). DNP24-BSA, thapsigargin, ionomycin, compound 48/80 and PMA were used as inducers for histamine release from mast cell. In our study, aegeline inhibited the histamine release from RBL-2H3 cells induced by DNP24-BSA. Indeed, aegeline showed strong inhibition when RBL-2H3 cells induced by Ca2+ stimulants such as thapsigargin and ionomycin. Aegeline is suggested to influence the intracellular Ca2+ pool only since could not inhibit the 45Ca2+ influx into RBL-2H3 cells. Aegeline showed weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin. These findings indicate that aegeline altered the signaling pathway related to the intracellular Ca2+ pool in which thapsigargin acts. Based on the results, the inhibitory effects of aegeline on the histamine release from mast cells depended on the type of mast cell and also involved some mechanisms related to intracellular Ca2+ signaling events via the same target of the action of thapsigargin or downstream process of intracellular Ca2+ signaling in mast cells. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Aegle marmelos Correa en_US
dc.subject aegeline, histamine release en_US
dc.subject mast cell en_US
dc.title EFFECTS OF AEGELINE, A MAIN ALKALOID OF AEGLE MARMELOS CORREA LEAVES, ON THE HISTAMINE RELEASE FROM MAST CELLS en_US
dc.type Article en_US


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