Abstract:
The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into
SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective
permeability coefficient obtained with that of drug solution and micellar solution. The prepared SMEDDS and
micelles formulations were investigated for droplets size. SPIP experiment was performed using the three
formulations in three of the secluded regions of the small intestine (duodenum, jejunum, and ileum). The
amount of the drug in the samples was estimated by HPLC and the effective permeability coefficients in rats
were calculated. The human intestinal permeability was predicted based on rat effective permeability coefficient
value. The dilution stability of the formulations was also determined. The average droplet size of SMEDDS and
micelles was 9.27 nm and 7.20 nm respectively. The effective permeability coefficient of sulpiride was
appreciably lower in the ileum weighed against jejunum and duodenum when administered as a solution
(p<0.05). The estimated human absorption of sulpiride for the SMEDDS dilutions was superior to that from
solution (p<0.05) and similar to micellar solution. The micellar dilutions were unstable whereas the SMEDDS
dilutions were stable. Based on the above results, SMEDDS can be a potential candidate for improving the
peroral absorption of the sulpiride.
