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FLAVONOIDS OF ENHYDRA FLUCTUANS EXHIBITS ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY IN DIFFERENT ANIMAL MODELS

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dc.contributor.author SANTANU SANNIGRAHI
dc.contributor.author MAZUMDER, UPAL KANTI
dc.contributor.author DILIPKUMAR PAL
dc.contributor.author SILPI LIPSA MISHRA
dc.contributor.author SUBHASIS MAITY
dc.date.accessioned 2023-01-20T07:39:12Z
dc.date.available 2023-01-20T07:39:12Z
dc.date.issued 2011-07-20
dc.identifier.citation Sannigrahi, S., Mazumder, U. K., Pal, D., Mishra, S. L., & Maity, S. (2011). Flavonoids of Enhydra Fluctuans exhibits analgesic and anti-inflammatory activity in different animal models. Pakistan Journal of Pharmaceutical Sciences, 24(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16427
dc.description.abstract Enhydra fluctuans (Compositae), an edible semi aquatic herbaceous vegetable plant, widely used in traditional system of Indian medicine. Total flavonoids of E. fluctuans (TFEF) were screened for analgesic and antiinflammatory activity. Analgesic activity was studied in acetic acid induced writhing response and by hot plate method in Swiss albino mice. Anti-inflammatory activity was estimated by carrageenan and histamine induced acute inflammation and Freund’s complete adjuvant (FCA) induced chronic inflammation in rats. Two flavonoids, baicalein 7-O-glucoside and baicalein 7-O-diglucoside, were isolated from the ethyl acetate fraction. Oral administration of TFEF at the doses of 200 and 400 mg/kg provide 27.05 and 55.49% protection respectively in acetic acid induced writhing method. It also increased the pain threshold in mice evidenced by hot plate method. TFEF showed more potent anti-inflammatory activity. The results of this study may be attributed to high free radical scavenging and antioxidant potential of the flavonoids present in ethyl acetate fraction of Enhydra fluctuans. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Enhydra fluctuans en_US
dc.subject adjuvant arthritis en_US
dc.subject flavonoids, analgesic en_US
dc.subject anti-inflammatory potential en_US
dc.title FLAVONOIDS OF ENHYDRA FLUCTUANS EXHIBITS ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY IN DIFFERENT ANIMAL MODELS en_US
dc.type Article en_US


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