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HEPATOPROTECTIVE STUDIES ON HALOXYLON SALICORNICUM: A PLANT FROM CHOLISTAN DESERT

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dc.contributor.author MAHMOOD AHMAD
dc.contributor.author SOFIA ERAM
dc.date.accessioned 2023-01-20T07:40:00Z
dc.date.available 2023-01-20T07:40:00Z
dc.date.issued 2011-07-20
dc.identifier.citation Ahmad, M., & Eram, S. (2011). Hepatoprotective studies on Haloxylon Salicornicum: a plant from Cholistan desert. Pakistan journal of pharmaceutical sciences, 24(3). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16430
dc.description.abstract The objective was to study the in-vivo hepatoprotective effect of aerial parts of Haloxylon salicornicum (Moq.) Bunge (Family: Chenopodiaceae) in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan desert, Pakistan. Aerial parts (ethanolic extract) of Haloxylon salicornicum (HS), (500 and 750 mg/kg/day, p.o. for 7 days) were evaluated on CCl4 intoxicated rabbits (0.75 ml/kg., s/c.) by serum biochemical parameters and liver histopathological observations. Silymarin (100 mg/kg/day, p.o. for 7 days) was used as a standard hepatoprotective drug. CCl4 intoxicated group had elevated levels of SGOT, SGPT and ALP significantly but TB level was normal as compared to control group. HS extract (both doses of 500 and 750 mg/kg) showed hepatoprotective effect by significant restoration of SGOT, SGPT, ALP and TB levels as compared to CCl4 control. 500 mg/kg doses of HS extract produced more significant results as compared to 750 mg/kg doses and Silymarin. Histopathological examination of liver tissues further substantiated these findings. Therefore, outcome of the present study validate the traditional claims on hepatoprotective effects of Haloxylon salicornicum (aerial parts). en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Haloxylon salicornicum en_US
dc.subject Hepatoprotection en_US
dc.subject Carbon tetrachloride en_US
dc.subject Serum biochemical parameters en_US
dc.subject Histopathology of liver. en_US
dc.title HEPATOPROTECTIVE STUDIES ON HALOXYLON SALICORNICUM: A PLANT FROM CHOLISTAN DESERT en_US
dc.type Article en_US


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