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Design, characterization and in-vitro evaluation of different cellulosic acrylic and methacrylic polymers loaded aceclofenac microspheres

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dc.contributor.author Irin Dewan
dc.contributor.author Salim Miah
dc.contributor.author SM Ashraful Islam
dc.contributor.author Sohel Rana
dc.date.accessioned 2023-01-20T08:06:23Z
dc.date.available 2023-01-20T08:06:23Z
dc.date.issued 2014-09-20
dc.identifier.citation Dewan, I., Miah, S., Islam, S. M., & Rana, S. (2014). Design, characterization and in-vitro evaluation of different cellulosic acrylic and methacrylic polymers loaded aceclofenac microspheres. Pakistan Journal of Pharmaceutical Sciences, 27(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16456
dc.description.abstract The aspire of this attempt was to design and evaluate aceclofenac loaded sustained release microspheres by emulsion solvent evaporation method, using different polymers like Ethyl cellulose (EC), Kollidon SR (KSR), Eudragit RS 100, Eudragit RL 100 and Hydroxypropylmethyl Cellulose (HPMC K100M). Microspheres were prepared using different stirring rate (1200, 1500, 2000rpm) and larger microspheres were obtained with lower stirring rate.Performance of microspheres was evaluated in terms of in vitro dissolution study which was allowed according to USP paddle method using Phosphate Buffer (pH 6.8) for 8 hours. UV-spectrophotometric method was used to calculate the drug content and the maximum and minimum release of aceclofenac from microspheres was observed 96.08% and 46.41% for formulation F18 and F5 after 8 hours respectively. Dissolution data were fitted by different mathematical models such as the zero order plot, first order plot, Higuchi plot, Hixon-Crowel plot and korsemeyer plot. Korsemeyer model has found to best fitted with release data. Scanning electron microscopic technique was performed to obtain the particle size and morphological changes due to different polymers. Fourier Transform Infra-red (FT-IR) spectroscopy was performed to find out any interaction of drug with the polymers. The drug might be released by both diffusion and erosion as data were best fitted with Korsemeyer model. So it has been demonstrated that aceclofenac microspheres containing different cellulosic, acrylic and methacrylic loaded polymers may be excellent candidates for consideration in drug delivery systems. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Aceclofenac en_US
dc.subject microspheres en_US
dc.subject emulsion solvent evaporation method en_US
dc.subject Korsemeyer model en_US
dc.title Design, characterization and in-vitro evaluation of different cellulosic acrylic and methacrylic polymers loaded aceclofenac microspheres en_US
dc.type Article en_US


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