PASTIC Dspace Repository

Preliminary investigations of banana (Musa paradisiaca) starch mucilage as binder in metformin tablet formulation

Show simple item record

dc.contributor.author Eraga, Sylvester Okhuelegbe
dc.contributor.author Arhewoh, Matthew Ikhuoria
dc.contributor.author Agboola, Janet Olamiposi
dc.contributor.author Iwuagwu, Magnus Amara
dc.date.accessioned 2023-01-20T09:13:32Z
dc.date.available 2023-01-20T09:13:32Z
dc.date.issued 2018-11-17
dc.identifier.citation Eraga, S. O., Arhewoh, M. I., Agboola, J. O., & Iwuagwu, M. A. (2018). Preliminary investigations of banana (Musa paradisiaca) starch mucilage as binder in metformin tablet formulation. Pakistan Journal of Pharmaceutical Sciences, 31(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16484
dc.description.abstract The binding properties of banana (Musa paradisiaca) starchwas investigated using maize starch BP and polyvinylpyrrolidone (PVP) as standards in the formulation of metformin tablets. Starch from unripe banana fruits was extracted with distilled water. Mucilages of the banana and maize starches and solutions of PVP at 5 and 10 %w/v were used to produce metformin granules by wet granulation and compressed into tablets. Granules and tablets properties were evaluated. Compatibility studies using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were also carried out. Granules flow properties was of the order: PVP >banana starch > maize starch. DSC and FTIR analysis reveals no interaction between excipients and metformin. Increase in concentration of banana starch mucilage from 5-10% w/v led to an increase in hardness, disintegration time and decrease in friability of the tablets. Tablets of banana starch mucilages were comparable in tablet properties with those of maize starch mucilages and PVP solutions with no significant differences (p<0.05). The tablets exhibited crushing strength, friability and disintegration time values ranging from 6.75-12.00 kp, 0.82-1.50 % and 11.04-14.51 min, respectively. The tablet parameters met compendial requirements at binder concentrations studied except friability values for tablets of PVP. Results revealed that banana starch could be used as a binding agent in metformin tablet formulation due to its comparable binding property with maize starch BP and PVP. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Banana starch en_US
dc.subject characterisation en_US
dc.subject mucilage en_US
dc.subject metformin en_US
dc.subject tablets en_US
dc.title Preliminary investigations of banana (Musa paradisiaca) starch mucilage as binder in metformin tablet formulation en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account