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Evaluation of fast disintegrating tablets of paracetamol prepared from a blend of croscarmellose sodium and Pleurotus tuber-regium powder

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dc.contributor.author Eraga, Sylvester Okhuelegbe
dc.contributor.author Arhewoh, Matthew Ikhuoria
dc.contributor.author Akpan, Faith Emmanuel
dc.contributor.author Iwuagwu, Magnus Amara
dc.date.accessioned 2023-01-20T09:16:14Z
dc.date.available 2023-01-20T09:16:14Z
dc.date.issued 2018-11-26
dc.identifier.citation Eraga, S. O., Arhewoh, M. I., Akpan, F. E., & Iwuagwu, M. A. (2018). Evaluation of fast disintegrating tablets of paracetamol prepared from a blend of croscarmellose sodium and Pleurotus tuber-regium powder. Pak J Pharm Sci, 31(6), 2503-2508. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16492
dc.description.abstract The study investigated the combination effects of the mixture of croscarmellose sodium and Pleurotus tuberregium powder on the granules and tableting parameters of paracetamol tablets. Five batches (A-E) of paracetamol tablets were formulated using wet granulation method with various combination ratios of croscarmellose sodium and Pleurotus tuber-regium powder as disintegrant incorporated both intra- and extra granularly. Their granule properties such as bulk and tapped densities, angle of repose, Carr’s index, Hausner’s ratio and post compression parameters such as friability, hardness, disintegration time and drug release profiles were evaluated. The results showed a decrease in disintegration time with increasing concentration of Pleurotus tuber-regium powder with disintegration times ≤ 3.58 min. There was an increase in hardness (values ≥ 4.34 kp) and a decrease in friability (values ≤ 0.6 %) of the tablets with increasing ncentrations of Pleurotus tuber-regium. All the tablets exhibited comparable drug release profiles with over 80 % of their drugs released in 1 h. Harder and less friable fast disintegrating tablets of paracetamol can be btained with Pleurotus tuber-regium powder in combination with croscarmellose sodium. The combination of croscarmellose sodium and Pleurotus tuber-regium possesses potentiative effect on their disintegrant activity. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Pleurotus tuber-regium en_US
dc.subject croscarmellose sodium en_US
dc.subject combination en_US
dc.subject combination en_US
dc.subject tablet en_US
dc.title Evaluation of fast disintegrating tablets of paracetamol prepared from a blend of croscarmellose sodium and Pleurotus tuber-regium powder en_US
dc.type Article en_US


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