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The effects of gabapentin on severity of post spinal anesthesia headache

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dc.contributor.author Sepideh Vahabi
dc.contributor.author Sedigheh Nadri
dc.contributor.author Fatemeh Izadi
dc.date.accessioned 2023-01-20T09:18:35Z
dc.date.available 2023-01-20T09:18:35Z
dc.date.issued 2014-09-20
dc.identifier.citation Vahabi, S., Nadri, S., & Izad, F. (2014). The effects of gabapentin on severity of post spinal anesthesia headache. Pakistan Journal of Pharmaceutical Sciences, 27(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16501
dc.description.abstract Spinal anesthesia is a common anesthesia method and post dural puncture headache (PDPH) is one of its most common adverse effects. Gabapentin is a popular anticonvulsant drug that has been used as an oral nonopioid analgesic in recent years. In this placebo-controlled double-blind study, 120 patients were randomized in two equal groups (Placebo or gabapentin). The patients in the gabapentin group received gabapentin 300 mg orally one hour before the surgery and then every 12 hours for the first 24 hours after the surgery while the placebo group received placebos in the same way. Severity of headache and postoperative pain assessed by verbal rating score for pain (VRSP), morphine consumption, nausea, vomiting, somnolence, pruritus, dizziness in the first 48 hours, hypertension, hypotension, bradycardia and tachycardia in the first 24 hours after the surgery were recorded. In first 48 hour after surgery the mean of severity of headache in the gabapentin group was 0.20±0.05, and in the placebo group it was 0.93±0.01. The mean of postoperative pain in the gabapentin group was2.25±0.793, and in the placebo group it was3.77±0.813. In the first 24 hours post operative the mean of morphine consumptions were 0.20±0.030 and 0.32±0.0 30 mg in gabapentin and placebo groups. No significant differences were found between the two groups regarding incidence rate of the adverse effects. In this study, administration of gabapentin decreased the incidence and severity of post spinal anesthesia headache, postoperative pain and morphine consumption, without any significant differences in serious adverse effects. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject post spinal anesthesia headache en_US
dc.subject gabapentin en_US
dc.subject spinal anesthesia. en_US
dc.title The effects of gabapentin on severity of post spinal anesthesia headache en_US
dc.type Article en_US


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