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REPORT Safety and toxicological evaluation of herbal formulation on rodents

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dc.contributor.author Farzana Sadaf
dc.contributor.author Sumbul Shamim
dc.contributor.author Rubeena Saleem
dc.contributor.author Navaid-ul-Zafar
dc.date.accessioned 2023-01-20T09:18:49Z
dc.date.available 2023-01-20T09:18:49Z
dc.date.issued 2018-12-02
dc.identifier.citation Sadaf, F., Shamim, S., & Saleem, R. (2018). Safety and toxicological evaluation of herbal formulation on rodents. Pakistan Journal of Pharmaceutical Sciences, 31(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16502
dc.description.abstract Herbal medicines are still most popular, abundant and affordable remedies for curing various ailments. Garlina is one of the herbal formulations of Hamdard Laboratories (waqf) Pakistan used to treat cardiovascular diseases and elevated sugar level. However, there is no scientific data available regarding the potential toxicity. Therefore, the present study was to assess the acute and sub-chronic toxicity in rats. The single dose of Garlina 5000mg/kg were administered orally and observed for 14 days. A sub-chronic toxicity test was performed at 2000mg/kg of Garlina daily for 30 days. Control rats received saline. The biochemical, hematological and histopathological analysis was carried out. The acute toxicity LD50 was determined to be >5000mg/kg. The result of acute and sub-chronic toxicity revealed no mortality and sign of toxicity. Garlina did not elicit any significant change in body weight, hematological and histopathology analysis when compared to saline treated rats. The relative weight of organs was not affected by the treatment. While the daily dose of Garlina for humans is 20mg/kg. However, the sub-chronic toxicity at 2000mg/kg dose of Garlina exhibited significant increase in gamma glutamyltransferase while total protein significantly decreased. Results obtained from study demonstrated that there is wide margin of safety for the therapeutic use of Garlina and significant decrease in LDL, atherogenic index, GGT and bilirubin direct at the dose of 5000mg/kg further strengthen the use as hypolipidemic and hypoglycemic agent. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Garlina en_US
dc.subject acute en_US
dc.subject sub- chronic toxicity en_US
dc.subject biochemical en_US
dc.subject hematology en_US
dc.subject histopathology en_US
dc.title REPORT Safety and toxicological evaluation of herbal formulation on rodents en_US
dc.type Article en_US


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