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REPORT Attenuation of apomorphine induced behavioral sensitization in rats pre-treated with tryptophan

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dc.contributor.author Muhammad Farhan
dc.contributor.author Darakshan Jabeen Haleem
dc.date.accessioned 2023-01-20T09:19:46Z
dc.date.available 2023-01-20T09:19:46Z
dc.date.issued 2018-12-04
dc.identifier.citation Farhan, M., & Haleem, D. J. (2018). Attenuation of apomorphine induced behavioral sensitization in rats pre-treated with tryptophan. Pakistan Journal of Pharmaceutical Sciences, 31(6). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16506
dc.description.abstract Psychostimulants substances, some of which are abused by humans, are generally believed to produce sensitization effects when they are repeatedly administered to animals. Apomorphine, a non-narcotic derivative of morphine, having agonistic property for dopamine in order to produce psycho stimulant-like effects. Meanwhile, chronic administration leads to behavioral sensitization. Therefore, present study destine to produce desensitization in animals by the repeated administration of tryptophan (100 mg/kg), thereafter treated with apomorphine (1.0 mg/kg) to observe the intensity of sensitization in rats pre-treated with tryptophan. Apomorphine on acute administration known to increase motor activity whereas repeated treatment of apomorphine initiates the sensitization of motor behavior. It is expected that the intensity of apomorphine induced sensitization would be affected in tryptophan-treated rats. Present study provide the clear-cut evidence that chronic treatment of apomorphine arouses the motor behavior of animals in both novel and anxiolytic model over the saline treated animals, whereas hypo locomotive behavior was seen in animals pre-treated with tryptophan, provides the evidence that preliminary treatment of tryptophan perturbs the apomorphine induced sensitization in animals. The discoveries present an inventive methodology for amplifying the remedial utilization of apomorphine and traditional psychostimulants. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Sensitization en_US
dc.subject Desensitization en_US
dc.subject Apomorphine en_US
dc.subject Tryptophan en_US
dc.subject Locomotor activity en_US
dc.title REPORT Attenuation of apomorphine induced behavioral sensitization in rats pre-treated with tryptophan en_US
dc.type Article en_US


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