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REPORT A comparative study of loratidine physiochemical properties from different brands

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dc.contributor.author Safila Naveed
dc.contributor.author Huma Dilshad
dc.contributor.author Sheeba Urooj
dc.date.accessioned 2023-01-20T09:19:59Z
dc.date.available 2023-01-20T09:19:59Z
dc.date.issued 2018-12-05
dc.identifier.citation Naveed, S., Dilshad, H., & Urooj, S. (2018). A comparative study of loratidine physiochemical properties from different brands. Pakistan Journal of Pharmaceutical Sciences, 31(6), 2569-2574. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16507
dc.description.abstract Loratidine is a piperidine derivative resemble to azatadine long acting non sedating commonly used for the treatment of allergic condition like watery or itchy eyes, runny nose, chronic urticaria or throat itching. In the present study different brands of loratidine were evaluated for the weight variation, hardness, friability, disintegration time and dissolution. Dissolution release study performed by using paddle method (USP 2) in 900 ml of 0.1N HCl at 50 rpm. The physicochemical of loratidine did not give any variation. By this study we conclude that all parameter for physicochemical properties like weight variation, hardness of tablets, friability, their disintegration time and the dissolution release study for all the brands of loratidine that are available in Karachi meet the British pharmacopoeia (BP) and United State pharmacopoeia (USP) specification for quality control analysis.Weight variation, hardness and friability value requirement was complied by all brands .Disintegration time for all brands was less than 15 minutes complying the BP/USP recommendation. All brands showed more than 80 % drug release within 45 minutes. The present findings suggest that almost all the brands of loratidine meet the BP/USP specification for QC analysis. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Loratidine en_US
dc.subject pharmaceutical formulations en_US
dc.subject comparative study en_US
dc.title REPORT A comparative study of loratidine physiochemical properties from different brands en_US
dc.type Article en_US


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