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Preparation, characterization and in vitro cytotoxicity assay of curcumin loaded solid lipid nanoparticle in IMR32 neuroblastoma cell line

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dc.contributor.author Rahman, Mohamed Habibur
dc.contributor.author Muthiah Ramanathan
dc.contributor.author Veintramuthu Sankar
dc.date.accessioned 2023-01-20T09:21:06Z
dc.date.available 2023-01-20T09:21:06Z
dc.date.issued 2014-09-20
dc.identifier.citation Rahman, M. H., Ramanathan, M., & Sankar, V. (2014). Preparation, characterization and in vitro cytotoxicity assay of curcumin loaded solid lipid nanoparticle in IMR32 neuroblastoma cell line. Pakistan journal of pharmaceutical sciences, 27(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16511
dc.description.abstract Curcumin (diferuloylmethane) possesses low bioavailability due to its poor solubility, permeability and rapid metabolism. Solid Lipid Nanoparticle of curcumin was prepared by high-speed homogenization technique. Stearic acid was used as a lipid, tween 80 as surfactant and various co surfactants were used for the preparation of SLN. The prepared SLN was characterized using zeta sizer, TEM analysis and the average particle size was found to be in the range of 80 nm – 200nm. The entrapment efficiency of the SLN was ~58 to 85%. The characteristic FTIR peaks suggest that the stearic acid is compatible with curcumin. MTT assay was performed on the optimized formulation and the results are indicative that curcumin SLN showed better cytotoxicity in low dose while compared to plain curcumin. The developed Cu-SLN can find its better place in the anticancer therapy. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Curcumin en_US
dc.subject solid lipid nanoparticle en_US
dc.subject stearic acid en_US
dc.subject tween 80 en_US
dc.subject co surfactants en_US
dc.title Preparation, characterization and in vitro cytotoxicity assay of curcumin loaded solid lipid nanoparticle in IMR32 neuroblastoma cell line en_US
dc.type Article en_US


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