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Anti-nociceptive and anti-inflammatory activities of the extracts of Stauntonia chinensis

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dc.contributor.author Chen Ying
dc.contributor.author Wu Ning
dc.contributor.author Liu Ying
dc.contributor.author Gao Hao
dc.contributor.author Jin, Dong Hua
dc.contributor.author Bin, Su Rui
dc.contributor.author Sheng, Yao Xin
dc.contributor.author Li Jin
dc.date.accessioned 2023-01-20T09:23:45Z
dc.date.available 2023-01-20T09:23:45Z
dc.date.issued 2014-09-20
dc.identifier.citation Ying, C., Ning, W., Ying, L., Hao, G., Hua-Jin, D., Rui-Bin, S., ... & Jin, L. (2014). Anti-nociceptive and anti-inflammatory activities of the extracts of Stauntonia chinensis. Pakistan Journal of Pharmaceutical Sciences, 27(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16516
dc.description.abstract The aim of this investigation was to study the anti-nociceptive and anti-inflammatory activities of Stauntonia chinensis (S. chinensis) and the possible action mechanisms of effective fractions. The anti-nociceptive and antiinflammatory activities of S. chinensis extracts, including the 60% EtOH extract (YMG), the n-BuOH extract (YMGB) and the aqueous residue (YMGW) of YMG, and the fractions from YMGB (YMGB1~YMGB7) were investigated by using the mouse acetic acid-induced writhing test and the rat formalin test. The effect of these extracts on the PGE2 production was tested as well. In the mouse acetic acid-induced writhing test and the rat formalin test, YMGW and YMGB displayed anti-nociceptive and anti-inflammatory activities, suggesting that they were the active ingredients of YMG. Among the fractions isolated from YMGB, YMGB1, YMGB3, YMGB4 and YMGB6 were the main active ingredients producing anti-nociceptive activity and YMGB3, YMGB5, YMGB6 and YMGB7 were the main active ingredients producing anti-inflammatory activity. Additionally, YMGW, YMGB and its separations reduced the production of PGE2, which might be the mechanism of them producing anti-inflammatory activity. These results demonstrated the active ingredients of S. chinensis producing anti-nociceptive and anti-inflammatory activities, which is valuable to validate the substance basis of S. chinensis’s pharmacological actions. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Stauntonia chinensis DC en_US
dc.subject Antinociceptive activity en_US
dc.subject Anti-inflammatory activity en_US
dc.subject PGE2 production en_US
dc.title Anti-nociceptive and anti-inflammatory activities of the extracts of Stauntonia chinensis en_US
dc.type Article en_US


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