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Prostate cancer: Leading and misleading routes to TRAIL of death

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dc.contributor.author Farooq, Ammad Ahmad
dc.contributor.author Qureshi, Muhammad Zahid
dc.contributor.author Abdur Rehman
dc.contributor.author Nogueira, Daniele Rubert
dc.contributor.author Awan, Imrana Iftikhar
dc.contributor.author Adeela Shahid
dc.date.accessioned 2023-01-20T09:27:14Z
dc.date.available 2023-01-20T09:27:14Z
dc.date.issued 2014-09-20
dc.identifier.citation Ammad, F., Muhammad, Q., Abdur, R., Daniele, N., Imrana, A., & Adeela, S. (2014). Prostate cancer: Leading and misleading routes to TRAIL of death. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16520
dc.description.abstract Prostate cancer is a multifaceted disease that arises because of misrepresentation of linear and integrated signaling cascades that regulate gene network in normal and cancer cells. Programmed cell death is modulated by intracellular regulators within each cell and various lines of evidence suggest that there is under- expression and overexpression of pro-apoptotic and anti-apoptotic gene subsets respectively. Apoptosis is a response to the cellular microenvironment, and the cell microenvironment can be regulated by multiple signaling cascades at a higher organizational level by suppressing survival signals notably at genetic, epigenetic, transcriptional and post-transcriptional level. Unquestionably, drug-discovery approaches over the last decade aiming at neutralizing anti-apoptotic proteins, over-expressing pro-apoptotic proteins and enhancing the cell surface appearance of TRAIL receptors have revolutionized our current information about inducing and maximizing TRAIL mediated signaling in resistant prostate cancer phenotype. In this mini-review we outline outstanding developments in the field of prostate cancer that have played a rolein understanding the underlying mechanisms that control TRAIL mediated apoptosis in prostate cancer cells, which may be helpful in the development of cancer therapies based on the apoptotic pathway en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject TRAIL, apoptosis en_US
dc.subject targeted therapy en_US
dc.subject signaling cascades en_US
dc.title Prostate cancer: Leading and misleading routes to TRAIL of death en_US
dc.type Article en_US


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