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Renin Angiotensin Aldosterone System (RAAS): Its biology and drug targets for treating diabetic nephropathy

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dc.contributor.author Maryam Zain
dc.contributor.author Awan, Fazli Rabbi
dc.date.accessioned 2023-01-20T09:27:47Z
dc.date.available 2023-01-20T09:27:47Z
dc.date.issued 2014-09-20
dc.identifier.citation Zain, M., & Awan, F. R. (2014). Renin Angiotensin Aldosterone System (RAAS): its biology and drug targets for treating diabetic nephropathy. Pakistan journal of pharmaceutical sciences, 27(5). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16521
dc.description.abstract Diabetes mellitus is a multifactorial disorder of hyperglycemia caused by a combination of biochemical, molecular and genetic factors, which leads to the dysfunction of various organs including kidneys. Diabetic nephropathy (DN) is one of the microvascular complications of diabetes that results due to poor glycemic control. Several molecular and biochemical pathways have been implicated in the pathogenesis of DN. Of these, the Renin Angiotensin Aldosterone System (RAAS) is considered as a key pathway. RAAS involves various subsystems which contribute to the development of DN. Mutations in several genes of the RAAS pathway have been associated with the development of DN. These genes or their products present them as therapeutic targets for potent drugs to control or prevent DN, and development of new drugs for targeting the RAAS. Drugs in use for DN are mainly the Angiotensin Converting Enzyme(ACE) inhibitors, Angiotensin Receptors Blockers (ARB) and renin inhibitors which play important roles in reducingDN. Hence, the present review is focused on the pathophysiology and genetic factors for DN by exploring the RAASpathway and emphasizing the benefits of blocking this pathway to control and prevent DN. en_US
dc.language.iso en en_US
dc.publisher Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. en_US
dc.subject Angiotensin en_US
dc.subject ACE en_US
dc.subject aldosterone en_US
dc.subject diabetic nephropathy en_US
dc.subject renin en_US
dc.title Renin Angiotensin Aldosterone System (RAAS): Its biology and drug targets for treating diabetic nephropathy en_US
dc.type Article en_US


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