PHARMACOKINETIC STUDY ABOUT INTERACTION OF NAPROXEN AND ISONIAZID

dc.contributor.author	MUHAMMAD TAYYAB ANSARI
dc.contributor.author	BASHIR AHMED LOOTHAR
dc.contributor.author	KHAN, QASIM JAHANGIR
dc.date.accessioned	2023-01-20T09:31:22Z
dc.date.available	2023-01-20T09:31:22Z
dc.date.issued	1999-01-05
dc.identifier.citation	ANSARI, M. T., LOOTHAR, B. A., & KHAN, Q. J. (1999). Pharmacokinetic study about interaction of Naproxen and Isoniazid. Pakistan Journal of Pharmaceutical Sciences, 12(1), 27-32.	en_US
dc.identifier.issn	1011-601X
dc.identifier.uri	http://142.54.178.187:9060/xmlui/handle/123456789/16526
dc.description.abstract	Effect of Naproxen (500 mg) was studied on the pharmacokinetic characteristics of Isoniazed (300 mg) in ten healthy human volunteers in a complete cross-over design. A high performance liquid chromatography (HPLC) method was used to analyze serum drug concentrations. Naproxen caused a highly significant (P<0.001) increase in AUC, significant (P<0.05) increase in elimination half life (t1/2) and time for the maximum drug concentration (tmax) while significant (P<0.05) decrease in elimination rate constant (Ke). Insignificant decrease and increase was observed in absorption rate constant (Ka) and maximum drug concentration (Cmax) respectively.	en_US
dc.language.iso	en	en_US
dc.publisher	Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi	en_US
dc.title	PHARMACOKINETIC STUDY ABOUT INTERACTION OF NAPROXEN AND ISONIAZID	en_US
dc.type	Article	en_US