SWELLING BEHAVIOUR OF pH-SENSITIVE CROSSLINKED POLY(VINYL ACETATE CO-ACRYLIC ACID) HYDROGELS FOR SITE SPECIFIC DRUG DELIVERY

dc.contributor.author	N.M. RANJHA
dc.date.accessioned	2023-01-20T09:31:38Z
dc.date.available	2023-01-20T09:31:38Z
dc.date.issued	1999-01-06
dc.identifier.citation	Ranjha, N. M. (1999). Swelling behaviour of pH-sensitive crosslinked poly (vinyl acetate co-acrylic acid) hydrogels for site specific drug delivery. Pakistan journal of pharmaceutical sciences, 12(1), 33-41.	en_US
dc.identifier.issn	1011-601X
dc.identifier.uri	http://142.54.178.187:9060/xmlui/handle/123456789/16527
dc.description.abstract	The present work was undertaken to combine nonionic vinyl acetate (VAC) with anionic acrylic acid (AA) or methacrylic acid (MAA) monomers in the presence of ethylen glycol dimethacrylate (EGDMA) as crosslinking agent through radical polymerization. Poly (vinyl acetate-co-acrylic acid) VAC/AA 50:50 to 100:0 six samples and Poly(vinvl acetatecomethacrylic acid) VAC/MAA one sample were prepared. All the samples were used for swelling studies. High swelling occurred at above pH 5.5 through chain relaxation. It was observed that swelling to VAC/MAA was lower than VAC/AA copolymers. The lower swelling in VAC/MAA copolymer is due to the presence of hydrophobic methyl group and higher pKa value of this copolymer.	en_US
dc.language.iso	en	en_US
dc.publisher	Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi	en_US
dc.title	SWELLING BEHAVIOUR OF pH-SENSITIVE CROSSLINKED POLY(VINYL ACETATE CO-ACRYLIC ACID) HYDROGELS FOR SITE SPECIFIC DRUG DELIVERY	en_US
dc.type	Article	en_US