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DNA repair, cancer and gene therapy

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dc.contributor.author S A Rasool
dc.contributor.author R Ali
dc.contributor.author A Mirza
dc.contributor.author T Yasmeen
dc.contributor.author R Mushtaque
dc.date.accessioned 2023-01-23T09:22:35Z
dc.date.available 2023-01-23T09:22:35Z
dc.date.issued 1992-07-11
dc.identifier.citation Limp‐Foster, M., & Kelley, M. R. (2000). DNA repair and gene therapy: implications for translational uses. Environmental and molecular mutagenesis, 35(2), 71-81. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16625
dc.description.abstract Fidelity of DNA synthesis is pivotal to our understanding of fundamental biological processes. An organism must replicate and repair its DNA with high accuracy and precision in order to maintain its genetic activity. DNA repair pathways enable cells to offer enhanced resistance to deleterious effects of chemicals and radiations (Lindahl, 1982). A number of pathways have been described e.g. the error-prone SOS repair (that lacks fidelity of repair process),the error-proof adaptive repair of alkylated DNA and inducible response to oxygen radical damage in DNA. These different circuits are under positive regulatory controls. However, the biochemical strategies employed to generate specific protein activators differ among the pathways. Although, the universally occurring repair activities seem to serve efficiently to counteract malignancy, error-prone polymerase and plasminogen activator have been instrumental in tumorigenesis, the process that proceeds by cascading of genetic errors (Sancar and Sancar, 1988). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.title DNA repair, cancer and gene therapy en_US
dc.type Article en_US


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