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Estimation of nor-adrenaline content of human penile tissue in diabeticmen with/without neuropathy

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dc.contributor.author S T Ali
dc.contributor.author R N Shaikh
dc.contributor.author N A Siddiqui
dc.contributor.author P Q Raza
dc.date.accessioned 2023-01-23T09:42:15Z
dc.date.available 2023-01-23T09:42:15Z
dc.date.issued 1994-07-04
dc.identifier.citation Ali, S. T., Shaikh, R. N., Siddiqui, N. A., & Raza, P. Q. (1994). Estimation of nor-adrenaline content of human penile tissue in diabeticmen with/without neuropathy. Pakistan Journal of Pharmaceutical Sciences, 7(2), 35-44. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16629
dc.description.abstract Penile tissue consisting of corps cavernosum (cc) and tunica albuginea (TA) was obtained from 35 impotent patients undergoing surgery for implantation of penile prostheses and was examined for nor adrenaline content. 10 patients were classified as a non diabetic non neuropathic group, on the basis of their clinical history and differential diagnostic symptoms which included Peyronie's disease, vascular disease, hypertension and psychogenic impotence. The nor adrenaline content was found to be significantly lower in tunica albuginea than the corpus cavernosum (P<0.02) in this group. The nor adrenaline content of corpus cavernosum from insulin dependent (IDDM) and non insulin dependent (NIDDM) diabetic neuropathic patients was also found to be significantly lower (P <0.02) than that of non diabetic non neuropathic patients. The nor adrenaline content of tunica albuginea however, was similar in both groups. A non significant association in the content of nor adrenaline in corpus cavernosum and tunica albuginea among IDDM and NIDDM diabetic neuropathics was also observed. These results provide evidence that an underlying neuropathic factor itself causes vascular as well as metabolic changes in the adrenergic nerves of the penis in diabetics due to neuropathy in addition to the effect of the disease and thus may contribute to the development of impotence in these patients irrespective of their type of diabetes. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.title Estimation of nor-adrenaline content of human penile tissue in diabeticmen with/without neuropathy en_US
dc.type Article en_US


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